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anti-Melanophilin (MLPH) Antibodies

MLPH encodes a member of the exophilin subfamily of Rab effector proteins. Additionally we are shipping Melanophilin Proteins (3) and Melanophilin Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLPH 171531 Q91V27
MLPH 316620  
MLPH 79083 Q9BV36
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Top anti-Melanophilin Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated EIA, IF, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in human stomach tissue (Formalin-fixed,... Western blot analysis in A375 cell line lysates (35ug/lane) using Mela... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MLPH Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:3... WB Suggested Anti-MLPH  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IHC (p), WB MLPH Antibody (C-term)  western blot analysis in A375 cell line lysate... MLPH Antibdy (C-term) immunohistochemistry analysis in formalin fixed ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Goat Un-conjugated ICC, IF, Pull-Down, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Mouse Goat Un-conjugated IF, ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Mouse Goat APC WB   100 μL Log in to see 16 Days
$713.43
Details

MLPH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
,
Rat (Rattus) , , ,
,
Human , , , ,
,

Top referenced anti-Melanophilin Antibodies

  1. Human Polyclonal MLPH Primary Antibody for EIA, IHC (p) - ABIN953384 : Park, Cai, McIntosh, Jabs, Fallin, Ingersoll, Hetmanski, Vekemans, Attie-Bitach, Lovett, Scott, Beaty: High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. in Journal of medical genetics 2006 (PubMed)
    Show all 5 references for ABIN953384

  2. Mouse (Murine) Polyclonal MLPH Primary Antibody for ELISA, WB - ABIN184753 : Matesic, Yip, Reuss, Swing, OSullivan, Fletcher, Copeland, Jenkins: Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 references for ABIN184753

  3. Mouse (Murine) Polyclonal MLPH Primary Antibody for EIA, IF - ABIN374219 : Figueiredo, Wasmeier, Tarafder, Ramalho, Baron, Seabra: Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 references for ABIN374219

  4. Human Polyclonal MLPH Primary Antibody for WB - ABIN611185 : Hamza, Prohaska, Gitlin: Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 references for ABIN611185

More Antibodies against Melanophilin Interaction Partners

Cow (Bovine) Melanophilin (MLPH) interaction partners

  1. a frameshifting deletion in the melanophilin gene accounts for a distinctive coat color in Belgian Blue cattle

Rabbit Melanophilin (MLPH) interaction partners

  1. A frameshift mutation within MLPH is responsible for the dilution of both eumelanic and pheomelanic pigmentations in rabbits.

  2. Two-exon skipping within MLPH is associated with coat color dilution in rabbits.

Mouse (Murine) Melanophilin (MLPH) interaction partners

  1. The results showed that Rab27A (show RAB27A Antibodies)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A Antibodies) effector Slac2-a/melanophilin.

  2. Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa (show MYO5A Antibodies) motors by 17-fold.

  3. Data suggest that Rab27a (show RAB27A Antibodies) and Rab27b (show RAB27B Antibodies) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A Antibodies)/Mlph/MyoVa (show MYO5A Antibodies) regulating cortical actin stability upstream of Rab27a/b (show RAB27A Antibodies)/Munc13-4 (show UNC13D Antibodies)-dependent granule exocytosis.

  4. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 Antibodies) homology domain (SHD (show SHD Antibodies)) (PMID: 11327731). The SHD (show SHD Antibodies) of Slac2-a specifically and directly binds the GTP (show AK3 Antibodies)-bound form of Rab27A (show RAB27A Antibodies) and Rab27B (show RAB27B Antibodies) (PMID: 11773082). The C-terminal domain directly binds myosin Va.

  5. The leaden gene product is required with Rab27a (show RAB27A Antibodies) to recruit myosin Va (show MYO5A Antibodies) to melanosomes in melanocytes

  6. myosin Va (show MYO5A Antibodies) binds to melanophilin and Rab27a (show RAB27A Antibodies)

  7. Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va (show MYO5A Antibodies) to melanosomes

  8. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 Antibodies)-bound form of Rab27A (show RAB27A Antibodies)

  9. Slac2-a organizes actin-based melanosome transport in cooperation with Rab27A, myosin Va, and actin

  10. cAMP stimulates the expression of Rab27a (show RAB27A Antibodies) and rapidly increases the interaction of the melanophilin/Slac2-a with actin

Human Melanophilin (MLPH) interaction partners

  1. The results showed that Rab27A (show RAB27A Antibodies)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A Antibodies) effector Slac2-a/melanophilin.

  2. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A (show RAB27A Antibodies).

  3. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 Antibodies) homology domain (SHD (show SHD Antibodies)) (PMID: 11327731). The SHD (show SHD Antibodies) of Slac2-a specifically and directly binds the GTP (show AK3 Antibodies)-bound form of Rab27A (show RAB27A Antibodies) and Rab27B (show RAB27B Antibodies) (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va (show MYO5A Antibodies).

  4. links rab27a (show RAB27A Antibodies) and myosin Va (show MYO5A Antibodies) function in melanosome transport

  5. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport.

  6. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 Antibodies)-bound form of Rab27A (show RAB27A Antibodies)

  7. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3 (show DNAJC21 Antibodies)) or a MYO5A (show MYO5A Antibodies) F-exon deletion (GS1 (show MYO5A Antibodies)).

  8. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27 (show RAB27A Antibodies)-containing organelles in the actin-enriched cell periphery.

Melanophilin (MLPH) Antigen Profile

Protein Summary

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with anti-Melanophilin (MLPH) Antibodies

  • melanophilin (MLPH) antibody
  • melanophilin (mlph) antibody
  • melanophilin (LOC100222096) antibody
  • melanophilin (LOC100343360) antibody
  • melanophilin (Mlph) antibody
  • 2210418F23Rik antibody
  • 5031433I09Rik antibody
  • AW228792 antibody
  • D1Wsu84e antibody
  • l(1)-3Rk antibody
  • l1Rk3 antibody
  • ln antibody
  • LOC100222096 antibody
  • MGC155106 antibody
  • Slac-2a antibody
  • SLAC2-A antibody

Protein level used designations for anti-Melanophilin (MLPH) Antibodies

melanophilin , exophilin-3 , leaden protein , slaC2-a , slp homolog lacking C2 domains a , synaptotagmin-like protein 2a

GENE ID SPECIES
424019 Gallus gallus
460048 Pan troglodytes
531343 Bos taurus
607077 Canis lupus familiaris
780791 Felis catus
100049680 Sus scrofa
100066385 Equus caballus
100145236 Xenopus (Silurana) tropicalis
100222096 Taeniopygia guttata
100272215 Ovis aries
100343360 Oryctolagus cuniculus
100590922 Nomascus leucogenys
171531 Mus musculus
316620 Rattus norvegicus
79083 Homo sapiens
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