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Melanophilin (MLPH) ELISA Kits

MLPH encodes a member of the exophilin subfamily of Rab effector proteins. Additionally we are shipping Melanophilin Antibodies (58) and Melanophilin Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MLPH 171531 Q91V27
Anti-Rat MLPH MLPH 316620  
MLPH 79083 Q9BV36
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Top Melanophilin ELISA Kits at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 78-5000 pg/mL 96 Tests Log in to see 11 to 13 Days
$875.60
Details
Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for Melanophilin Interaction Partners

Cow (Bovine) Melanophilin (MLPH) interaction partners

  1. a frameshifting deletion in the melanophilin gene accounts for a distinctive coat color in Belgian Blue cattle

Rabbit Melanophilin (MLPH) interaction partners

  1. A frameshift mutation within MLPH is responsible for the dilution of both eumelanic and pheomelanic pigmentations in rabbits.

  2. Two-exon skipping within MLPH is associated with coat color dilution in rabbits.

Mouse (Murine) Melanophilin (MLPH) interaction partners

  1. The results showed that Rab27A (show RAB27A ELISA Kits)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A ELISA Kits) effector Slac2-a/melanophilin.

  2. Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa (show MYO5A ELISA Kits) motors by 17-fold.

  3. Data suggest that Rab27a (show RAB27A ELISA Kits) and Rab27b (show RAB27B ELISA Kits) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A ELISA Kits)/Mlph/MyoVa (show MYO5A ELISA Kits) regulating cortical actin stability upstream of Rab27a/b (show RAB27A ELISA Kits)/Munc13-4 (show UNC13D ELISA Kits)-dependent granule exocytosis.

  4. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 ELISA Kits) homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP (show AK3 ELISA Kits)-bound form of Rab27A (show RAB27A ELISA Kits) and Rab27B (show RAB27B ELISA Kits) (PMID: 11773082). The C-terminal domain directly binds myosin Va.

  5. The leaden gene product is required with Rab27a (show RAB27A ELISA Kits) to recruit myosin Va (show MYO5A ELISA Kits) to melanosomes in melanocytes

  6. myosin Va (show MYO5A ELISA Kits) binds to melanophilin and Rab27a (show RAB27A ELISA Kits)

  7. Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va (show MYO5A ELISA Kits) to melanosomes

  8. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 ELISA Kits)-bound form of Rab27A (show RAB27A ELISA Kits)

  9. Slac2-a organizes actin-based melanosome transport in cooperation with Rab27A, myosin Va, and actin

  10. cAMP stimulates the expression of Rab27a (show RAB27A ELISA Kits) and rapidly increases the interaction of the melanophilin/Slac2-a with actin

Human Melanophilin (MLPH) interaction partners

  1. These results unravel a hidden link between AR and a functional putative PCa (show FLVCR1 ELISA Kits) risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.

  2. The results showed that Rab27A (show RAB27A ELISA Kits)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A ELISA Kits) effector Slac2-a/melanophilin.

  3. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A (show RAB27A ELISA Kits).

  4. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 ELISA Kits) homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP (show AK3 ELISA Kits)-bound form of Rab27A (show RAB27A ELISA Kits) and Rab27B (show RAB27B ELISA Kits) (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va (show MYO5A ELISA Kits).

  5. links rab27a (show RAB27A ELISA Kits) and myosin Va (show MYO5A ELISA Kits) function in melanosome transport

  6. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport.

  7. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 ELISA Kits)-bound form of Rab27A (show RAB27A ELISA Kits)

  8. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A (show MYO5A ELISA Kits) F-exon deletion (GS1 (show MYO5A ELISA Kits)).

  9. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27 (show RAB27A ELISA Kits)-containing organelles in the actin-enriched cell periphery.

Melanophilin (MLPH) Antigen Profile

Antigen Summary

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with Melanophilin (MLPH) ELISA Kits

  • melanophilin (MLPH) antibody
  • melanophilin (mlph) antibody
  • melanophilin (LOC100222096) antibody
  • melanophilin (LOC100343360) antibody
  • melanophilin (Mlph) antibody
  • 2210418F23Rik antibody
  • 5031433I09Rik antibody
  • AW228792 antibody
  • D1Wsu84e antibody
  • l(1)-3Rk antibody
  • l1Rk3 antibody
  • ln antibody
  • LOC100222096 antibody
  • MGC155106 antibody
  • Slac-2a antibody
  • SLAC2-A antibody

Protein level used designations for Melanophilin (MLPH) ELISA Kits

melanophilin , exophilin-3 , leaden protein , slaC2-a , slp homolog lacking C2 domains a , synaptotagmin-like protein 2a

GENE ID SPECIES
424019 Gallus gallus
460048 Pan troglodytes
531343 Bos taurus
607077 Canis lupus familiaris
780791 Felis catus
100049680 Sus scrofa
100066385 Equus caballus
100145236 Xenopus (Silurana) tropicalis
100222096 Taeniopygia guttata
100272215 Ovis aries
100343360 Oryctolagus cuniculus
100590922 Nomascus leucogenys
171531 Mus musculus
316620 Rattus norvegicus
79083 Homo sapiens
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