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Melanophilin Proteins (MLPH)

MLPH encodes a member of the exophilin subfamily of Rab effector proteins. Additionally we are shipping Melanophilin Antibodies (55) and Melanophilin Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLPH 171531 Q91V27
Rat MLPH MLPH 316620  
MLPH 79083 Q9BV36
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Top Melanophilin Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MLPH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Melanophilin (MLPH) Interaction Partners

Cow (Bovine) Melanophilin (MLPH) interaction partners

  1. a frameshifting deletion in the melanophilin gene accounts for a distinctive coat color in Belgian Blue cattle

Rabbit Melanophilin (MLPH) interaction partners

  1. A frameshift mutation within MLPH is responsible for the dilution of both eumelanic and pheomelanic pigmentations in rabbits.

  2. Two-exon skipping within MLPH is associated with coat color dilution in rabbits.

Mouse (Murine) Melanophilin (MLPH) interaction partners

  1. The results showed that Rab27A (show RAB27A Proteins)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A Proteins) effector Slac2-a/melanophilin.

  2. Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa (show MYO5A Proteins) motors by 17-fold.

  3. Data suggest that Rab27a (show RAB27A Proteins) and Rab27b (show RAB27B Proteins) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A Proteins)/Mlph/MyoVa (show MYO5A Proteins) regulating cortical actin stability upstream of Rab27a/b (show RAB27A Proteins)/Munc13-4 (show UNC13D Proteins)-dependent granule exocytosis.

  4. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slac2-a specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins) and Rab27B (show RAB27B Proteins) (PMID: 11773082). The C-terminal domain directly binds myosin Va.

  5. The leaden gene product is required with Rab27a (show RAB27A Proteins) to recruit myosin Va (show MYO5A Proteins) to melanosomes in melanocytes

  6. myosin Va (show MYO5A Proteins) binds to melanophilin and Rab27a (show RAB27A Proteins)

  7. Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va (show MYO5A Proteins) to melanosomes

  8. SHD1 (show SAC3D1 Proteins) of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins)

  9. Slac2-a organizes actin-based melanosome transport in cooperation with Rab27A, myosin Va, and actin

  10. cAMP stimulates the expression of Rab27a (show RAB27A Proteins) and rapidly increases the interaction of the melanophilin/Slac2-a with actin

Human Melanophilin (MLPH) interaction partners

  1. These results unravel a hidden link between AR and a functional putative PCa (show FLVCR1 Proteins) risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.

  2. The results showed that Rab27A (show RAB27A Proteins)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (show RAB27A Proteins) effector Slac2-a/melanophilin.

  3. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A (show RAB27A Proteins).

  4. Slac2-a/melanophilin contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slac2-a specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins) and Rab27B (show RAB27B Proteins) (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va (show MYO5A Proteins).

  5. links rab27a (show RAB27A Proteins) and myosin Va (show MYO5A Proteins) function in melanosome transport

  6. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport.

  7. SHD1 (show SAC3D1 Proteins) of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins)

  8. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A (show MYO5A Proteins) F-exon deletion (GS1 (show MYO5A Proteins)).

  9. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27 (show RAB27A Proteins)-containing organelles in the actin-enriched cell periphery.

Melanophilin (MLPH) Protein Profile

Protein Summary

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with Melanophilin Proteins (MLPH)

  • melanophilin (MLPH)
  • melanophilin (mlph)
  • melanophilin (LOC100222096)
  • melanophilin (LOC100343360)
  • melanophilin (Mlph)
  • 2210418F23Rik protein
  • 5031433I09Rik protein
  • AW228792 protein
  • D1Wsu84e protein
  • l(1)-3Rk protein
  • l1Rk3 protein
  • ln protein
  • LOC100222096 protein
  • MGC155106 protein
  • Slac-2a protein
  • SLAC2-A protein

Protein level used designations for Melanophilin Proteins (MLPH)

melanophilin , exophilin-3 , leaden protein , slaC2-a , slp homolog lacking C2 domains a , synaptotagmin-like protein 2a

GENE ID SPECIES
424019 Gallus gallus
460048 Pan troglodytes
531343 Bos taurus
607077 Canis lupus familiaris
780791 Felis catus
100049680 Sus scrofa
100066385 Equus caballus
100145236 Xenopus (Silurana) tropicalis
100222096 Taeniopygia guttata
100272215 Ovis aries
100343360 Oryctolagus cuniculus
100590922 Nomascus leucogenys
171531 Mus musculus
316620 Rattus norvegicus
79083 Homo sapiens
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