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May function in membrane fusion and regulate organelle biogenesis (By similarity). Additionally we are shipping MREG Antibodies (48) and and many more products for this protein.
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Taken together, MREG regulates thyroid cancer cell invasion and proliferation through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling pathway. MREG may serve as a promising therapeutic strategy for thyroid cancer.
MREG-dependent processing links both autophagic and phagocytic p (show MAP1LC3A Proteins)rocesses in (show ATG5 Proteins) LC3-associated phagocytosis. MREG participates in coordinating the (show RPE Proteins) assoc (show ATG5 Proteins)iation of p (show MAP1LC3A Proteins)hagosomes with LC3 for content degradation with the MREG loss leading to phagosome accumulation.
Single membrane POS containing phagosomes recruit endogenous LC3 (show MAP1LC3A Proteins) in an ATG5 (show ATG5 Proteins)-dependent manner that is dependent on MREG. In the Mregdsu/dsu RPE (show RPE Proteins), Atg5 (show ATG5 Proteins)/12 and LC3 (show MAP1LC3A Proteins) were increased relative to levels in the Mreg+/+ at all time points relative to light onset.
This study demonistrated that Loss of melanoregulin (MREG) enhances cathepsin-D (show CTSD Proteins) secretion by the retinal pigment epithelium.
The product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of BLOC-2 (show HPS6 Proteins) complex and with ocular albinism in regulating melanosome size.
Mreg regulates microtubule-dependent retrograde melanosome transport through the dynein-dynactin (show DCTN1 Proteins) motor complex.
multiple palmitoylation serves to stably anchor melanoregulin in the melanosome membrane.
Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes.
dsu identifies a unique protein involved in pigmentation of the mammalian hair
melanoregulin regulates peripherin-2 (show PRPH2 Proteins) function
Results suggest that melanoregulin (MREG) is required for lysosome maturation and support a role for MREG in intracellular trafficking.
May function in membrane fusion and regulate organelle biogenesis (By similarity).
, whn-dependent transcript 2-like
, dilute suppressor protein homolog
, whn-dependent transcript 2
, dilute suppressor protein