Membrane Metallo-Endopeptidase-Like 1 Proteins (MMEL1)

The protein encoded by MMEL1 is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Additionally we are shipping Membrane Metallo-Endopeptidase-Like 1 Antibodies (55) and Membrane Metallo-Endopeptidase-Like 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMEL1 79258 Q495T6
MMEL1 27390 Q9JLI3
Rat MMEL1 MMEL1 313755  
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Top Membrane Metallo-Endopeptidase-Like 1 Proteins at

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

MMEL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Membrane Metallo-Endopeptidase-Like 1 (MMEL1) Interaction Partners

Human Membrane Metallo-Endopeptidase-Like 1 (MMEL1) interaction partners

  1. the dynamic behavior of human NEP (show MME Proteins) and NEP2 proteins was monitored by conducting molecular dynamics (MD) simulations.

  2. MMEL1 518 Met/Thr (show TRH Proteins) polymorphism contributes to celiac disease risk among Saudi Arabians, both in single and also in synergistic cooperation with SH2B3 (show SH2B3 Proteins) gene marker.

  3. Te results of this study suggested taht genetic variations in MMEL1, ECE1 (show ECE1 Proteins), ECE2 (show ECE2 Proteins), AGER (show AGER Proteins), PLG (show PLG Proteins), PLAT (show PLAT Proteins), NR1H3 (show NR1H3 Proteins), MMP3 (show MMP3 Proteins), LRP1 (show LRP1 Proteins), TTR (show TTR Proteins), NR1H2 (show NR1H2 Proteins), and MMP9 (show MMP9 Proteins) genes do not play major role among the Finnish AD patient cohort.

  4. The NEP2 expression and activity are altered in MCI (show MCIN Proteins) is significant as these changes may potentially serve as preclinical markers for AD and reduced NEP2 activity may be associated with the development of Alzheimer's disease.

  5. This study identifies MMEL1 and CTLA4 as RA susceptibility genes, in Han Chinese popilation.

  6. A combined analysis of the nsSNP screen and replication data provides evidence implicating a novel additional locus, rs3748816 in membrane metalloendopeptidase (show THOP1 Proteins)-like 1 in multiple sclerosis susceptibility.

  7. NEP2 substrate specificity and inhibitor binding was distinct from that of human NEP (show MME Proteins), suggesting that NEP (show MME Proteins) and NEP2 play distinct physiological roles in humans.

Mouse (Murine) Membrane Metallo-Endopeptidase-Like 1 (MMEL1) interaction partners

  1. This study demonstrated that Cortical fast-spiking parvalbumin (show PVALB Proteins) interneurons enwrapped in the perineuronal net express the Neprilysin (show MME Proteins) in mice.

  2. neprilysin (show MME Proteins) x ABCC1 (show ABCC1 Proteins) double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  3. Data show that intranasal delivery of drugs can be used to model Alzheimer disease and suggest that other phosphoramidon-sensitive peptidases are degrading amyloid beta in neprilysin (show MME Proteins)/NEP2-deficient mice.

  4. In NEP (show MME Proteins)/NEP2 double-knockout mice, Abeta (show APP Proteins) levels were marginally increased ( approximately 1.5- to 2-fold), compared with NEP (show MME Proteins)(-/-)/NEP2(+/+) controls.

  5. One of the roles of NL1 in mice is related to sperm function. NL1 modulates the processes of fertilization and early embryonic development in vivo.

  6. Modification of the structure of the C-terminal region will either impair substrate hydrolysis or completely abolish the secretion and enzymatic activity of the secreted isoform of rat NEP2.

  7. Intracellular transport and secretion of NEP2 is regulated by processes such as glycosylation, endoplasmic reticulum-Golgi transport, and intracellular calcium levels.

Membrane Metallo-Endopeptidase-Like 1 (MMEL1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

Gene names and symbols associated with MMEL1

  • membrane metallo-endopeptidase-like 1 (mmel1)
  • membrane metallo-endopeptidase-like 1 (MMEL1)
  • membrane metallo-endopeptidase-like 1 (Mmel1)
  • Mell1 protein
  • MMEL1 protein
  • MMEL2 protein
  • NEP2 protein
  • NEPII protein
  • Nl1 protein
  • NL2 protein
  • SEP protein

Protein level used designations for MMEL1

membrane metallo-endopeptidase-like 1 , membrane metallo-endopeptidase-like 1-like , NEP2(m) , membrane metallo-endopeptidase-like 2 , neprilysin II , neprilysin-2 , soluble secreted endopeptidase , zinc metallopeptidase , NEPLP alpha , NEPLP beta , NEPLP gamma , NL-1 , NL2 , mel transforming oncogene-like 1 , neprilysin 2 , neprilysin-like 1 , neprilysin-like peptidase

560703 Danio rerio
616991 Bos taurus
744165 Pan troglodytes
770671 Gallus gallus
100028021 Monodelphis domestica
100054362 Equus caballus
100145721 Xenopus (Silurana) tropicalis
100397773 Callithrix jacchus
100437958 Pongo abelii
100512286 Sus scrofa
100549748 Meleagris gallopavo
79258 Homo sapiens
489617 Canis lupus familiaris
27390 Mus musculus
313755 Rattus norvegicus
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