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anti-Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) Antibodies

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). Additionally we are shipping MARCH1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MARCH1 72925 Q6NZQ8
MARCH1 55016 Q8TCQ1
MARCH1 361135  
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Top anti-MARCH1 Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB MARCH1 Antibody (Center) (ABIN658266) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the MARCH1 antibody detected the MARCH1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged MARCH1 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of 42064 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of 42064 expression in K562 (A), mouse brain (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$201.19
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details

MARCH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-MARCH1 Antibodies

  1. Mouse (Murine) Polyclonal MARCH1 Primary Antibody for WB - ABIN658266 : De Gassart, Camosseto, Thibodeau, Ceppi, Catalan, Pierre, Gatti: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 references for ABIN658266

  2. Human Polyclonal MARCH1 Primary Antibody for ELISA, WB - ABIN238660 : Matsuki, Ohmura-Hoshino, Goto, Aoki, Mito-Yoshida, Uematsu, Hasegawa, Koseki, Ohara, Nakayama, Toyooka, Matsuoka, Hotta, Yamamoto, Ishido: Novel regulation of MHC class II function in B cells. in The EMBO journal 2007 (PubMed)

More Antibodies against MARCH1 Interaction Partners

Mouse (Murine) Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) interaction partners

  1. March-I ubiquitination prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells

  2. IL-10 (show IL10 Antibodies) stimulates expression of the E3 ubiquitin ligase (show MUL1 Antibodies) March-I in activated macrophages, thereby down-regulating MHC-II, CD86 (show CD86 Antibodies), and antigen presentation to CD4 (show CD4 Antibodies) T cells.

  3. Dendritic cells co-cultivated with antigen-specific induced Tregs expressed high levels of MARCH1. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 (show IL10 Antibodies) on MARCH1 & CD83 (show CD83 Antibodies) expression.

  4. DCs deficient in MARCH1 or MHCII ubiquitination both failed to generate antigen-specific T reg (show KCNH2 Antibodies) cells in vivo and in vitro.

  5. aberrant degradation of spleen DCs MARCH1-mediated ubiquitinated proteins is involved during the earliest stage of MODS development.

  6. IL-10 can have opposite effects on MARCH1 regulation in different cell types.

  7. Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).

  8. found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1

  9. Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase (show MUL1 Antibodies) March-I results in the selective degradation of internalized pMHC-II.

  10. The function of MHC II in B cells is regulated through ubiquitination by MARCH-I.

Human Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) interaction partners

  1. findings highlight the complex regulation of MARCH1 trafficking in the endocytic pathway as well as the intricate interactions between its cytoplasmic tails.

  2. MARCH1 is capable of autoubiquitination, thus regulating its own expression.

  3. expression of MARCH1 or MARCH8 (show MARCH8 Antibodies) causes a drastic change CD98 (show SLC3A2 Antibodies) trafficking after endocytosis

  4. MARCH I is a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs.

  5. The immunosuppressive effect of IL-10 on antigen presentation is mediated through induced expression of MARCH1.

MARCH1 Antigen Profile

Protein Summary

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004

Gene names and symbols associated with MARCH1

  • membrane-associated ring finger (C3HC4) 1 (March1) antibody
  • membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase (MARCH1) antibody
  • membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase (March1) antibody
  • 2900024D24Rik antibody
  • BB085186 antibody
  • MARCH-I antibody
  • RGD1305148 antibody
  • RNF171 antibody

Protein level used designations for MARCH1

E3 ubiquitin-protein ligase MARCH1 , MARCH-I , membrane-associated RING finger protein 1 , membrane-associated RING-CH protein I , RING finger protein 171

GENE ID SPECIES
72925 Mus musculus
55016 Homo sapiens
361135 Rattus norvegicus
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