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MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 184.108.40.206). Additionally we are shipping Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase Proteins (6) and many more products for this protein.
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Cow (Bovine) Polyclonal MARCH2 Primary Antibody for WB - ABIN2775654
Wakisaka, Tsuda, Yamada, Yagihara, Kitamura: Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease. in Circulation journal : official journal of the Japanese Circulation Society 2008
Show all 2 references for ABIN2775654
Dog (Canine) Polyclonal MARCH2 Primary Antibody for WB - ABIN2774742
Cao, Huett, Kuballa, Giallourakis, Xavier: DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. in Cellular signalling 2007
Show all 2 references for ABIN2774742
Human Polyclonal MARCH2 Primary Antibody for WB - ABIN526579
Han, Xiao, Kim, Wu, Wisler, Nakamura, Freedman, Shenoy: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound ?(2)-adrenergic receptors. in The Journal of cell biology 2012
Human Polyclonal MARCH2 Primary Antibody for ELISA, WB - ABIN238602
Nakamura, Fukuda, Kato, Hirose: MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. in Molecular biology of the cell 2005
Data indicate that E3 ubiquitin ligase (show MUL1 Antibodies) MARCH2 co-immunoprecipitated and co-localized with CAL (show FBLIM1 Antibodies) and syntaxin 6 (STX6 (show STX6 Antibodies)), and show the ubiquitination of CFTR (show CFTR Antibodies) by MARCH2.
The MARCH2 E3 ligase activity regulates cell surface beta(2)AR expression and, consequently, its signaling.
Depletion of MARCH-II by small interfering RNA perturbed the trans-Golgi network (TGN (show TG Antibodies)) localization of syntaxin 6 (show STX6 Antibodies) and TGN38 (show TGOLN2 Antibodies)/46
MARCH2 is co-localized with DLG1 (show DLG1 Antibodies) at sites of cell-cell contact.
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004
E3 ubiquitin-protein ligase MARCH2
, membrane-associated RING finger protein 2
, membrane-associated RING-CH protein II
, RING finger protein 172
, membrane associated RING-CH finger protein II
, syntaxin-6-binding protein