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MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 184.108.40.206). Additionally we are shipping Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase Antibodies (51) and many more products for this protein.
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Data indicate that E3 ubiquitin ligase (show MUL1 Proteins) MARCH2 co-immunoprecipitated and co-localized with CAL (show FBLIM1 Proteins) and syntaxin 6 (STX6 (show STX6 Proteins)), and show the ubiquitination of CFTR (show CFTR Proteins) by MARCH2.
The MARCH2 E3 ligase activity regulates cell surface beta(2)AR expression and, consequently, its signaling.
Depletion of MARCH-II by small interfering RNA perturbed the trans-Golgi network (TGN (show TG Proteins)) localization of syntaxin 6 (show STX6 Proteins) and TGN38 (show TGOLN2 Proteins)/46
MARCH2 is co-localized with DLG1 (show DLG1 Proteins) at sites of cell-cell contact.
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004
E3 ubiquitin-protein ligase MARCH2
, membrane-associated RING finger protein 2
, membrane-associated RING-CH protein II
, RING finger protein 172
, membrane associated RING-CH finger protein II
, syntaxin-6-binding protein