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Membrane-Associated Ring Finger (C3HC4) 5 Proteins (MARCH5)

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MARCH5 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARCH5 54708 Q9NX47
MARCH5 69104 Q3KNM2
Rat MARCH5 MARCH5 294079  
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Top MARCH5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MARCH5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5) Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5) interaction partners

  1. MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after Viral hemorrhagic septicemia virus infection.

Human Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5) interaction partners

  1. Self-clearance mechanism of mitochondrial ligase MARCH5 contributes to mitochondria quality control.MARCH5 is regulated by auto-ubiquitination.

  2. MARCH5 binds MAVS (show MAVS Proteins) only during viral stimulation when MAVS (show MAVS Proteins) forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS (show MAVS Proteins).

  3. Our results indicate that HDAC6 (show HDAC6 Proteins) is a critical regulator of MFN2 (show MFN2 Proteins) degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress.

  4. A fine balance of Mfn1 (show MFN1 Proteins) levels is maintained by MARCH5-mediated quality control on acetylated Mfn1 (show MFN1 Proteins).

  5. MITOL regulates ER tethering to mitochondria by activating Mfn2 (show MFN2 Proteins) via K192 ubiquitination.

  6. balance between LC1 activation by S-nitrosylation and down-regulation by MITOL is critical for neuronal cell survival

  7. MARCH5 is an authentic E3 ubiquitin ligase (show MUL1 Proteins) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 (show TLR7 Proteins) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Proteins).

  8. study found that MITOL interacts with and ubiquitinates DeltaNAT-3Q71, a pathogenic ataxin-3 (show ATXN3 Proteins) mutant, in mitochondria and attenuates its toxicity

  9. lack of MARCH5 results in mitochondrial elongation, which promotes cellular senescence by blocking Drp1 (show CRMP1 Proteins) activity and/or promoting accumulation of Mfn1 (show MFN1 Proteins) at the mitochondria

  10. Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway.

Mouse (Murine) Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5) interaction partners

  1. MARCH5 binds MAVS (show MAVS Proteins) only during viral stimulation when MAVS (show MAVS Proteins) forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS (show MAVS Proteins).

  2. March5 is involved in maintaining mouse-ESC (mESC) pluripotency via catalysis of Prkar1a (show PRKAR1A Proteins) polyubiquitination and inhibition of the Raf (show RAF1 Proteins)/MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway.

  3. A fine balance of Mfn1 (show MFN1 Proteins) levels is maintained by MARCH5-mediated quality control on acetylated Mfn1 (show MFN1 Proteins).

  4. MARCH5 is an authentic E3 ubiquitin ligase (show MUL1 Proteins) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 (show TLR7 Proteins) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Proteins).

  5. Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway.

MARCH5 Protein Profile

Protein Summary

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006

Gene names and symbols associated with MARCH5

  • membrane-associated ring finger (C3HC4) 5 (march5)
  • membrane-associated ring finger (C3HC4) 5 (MARCH5)
  • membrane-associated ring finger (C3HC4) 5 (LOC100341637)
  • membrane-associated ring finger (C3HC4) 5 (March5)
  • 1810015H18Rik protein
  • 2310008I22Rik protein
  • 2700055A20Rik protein
  • 5730499H23Rik protein
  • E130202O05Rik protein
  • Mar-05 protein
  • MARCH-V protein
  • MARCH5 protein
  • Marchv protein
  • MITOL protein
  • Rnf153 protein
  • zgc:162966 protein

Protein level used designations for MARCH5

membrane-associated ring finger (C3HC4) 5 , E3 ubiquitin-protein ligase MARCH5 , MARCH-V , membrane-associated RING finger protein 5 , membrane-associated RING-CH protein V , mitochondrial ubiquitin ligase , ring finger protein 153

GENE ID SPECIES
100302643 Oncorhynchus mykiss
450607 Pan troglodytes
698517 Macaca mulatta
100144728 Xenopus (Silurana) tropicalis
100157340 Sus scrofa
100341637 Oryctolagus cuniculus
561952 Danio rerio
444564 Xenopus laevis
423815 Gallus gallus
54708 Homo sapiens
612766 Canis lupus familiaris
540937 Bos taurus
69104 Mus musculus
294079 Rattus norvegicus
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