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MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MARCH5 Antibodies (54) and many more products for this protein.
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MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after Viral hemorrhagic septicemia virus infection.
Self-clearance mechanism of mitochondrial ligase MARCH5 contributes to mitochondria quality control.MARCH5 is regulated by auto-ubiquitination.
MARCH5 binds MAVS (show MAVS Proteins) only during viral stimulation when MAVS (show MAVS Proteins) forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS (show MAVS Proteins).
Our results indicate that HDAC6 (show HDAC6 Proteins) is a critical regulator of MFN2 (show MFN2 Proteins) degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress.
A fine balance of Mfn1 (show MFN1 Proteins) levels is maintained by MARCH5-mediated quality control on acetylated Mfn1 (show MFN1 Proteins).
MITOL regulates ER tethering to mitochondria by activating Mfn2 (show MFN2 Proteins) via K192 ubiquitination.
balance between LC1 activation by S-nitrosylation and down-regulation by MITOL is critical for neuronal cell survival
MARCH5 is an authentic E3 ubiquitin ligase (show MUL1 Proteins) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 (show TLR7 Proteins) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Proteins).
study found that MITOL interacts with and ubiquitinates DeltaNAT-3Q71, a pathogenic ataxin-3 (show ATXN3 Proteins) mutant, in mitochondria and attenuates its toxicity
lack of MARCH5 results in mitochondrial elongation, which promotes cellular senescence by blocking Drp1 (show CRMP1 Proteins) activity and/or promoting accumulation of Mfn1 (show MFN1 Proteins) at the mitochondria
Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway.
March5 is involved in maintaining mouse-ESC (mESC) pluripotency via catalysis of Prkar1a (show PRKAR1A Proteins) polyubiquitination and inhibition of the Raf (show RAF1 Proteins)/MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway.
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006
membrane-associated ring finger (C3HC4) 5
, E3 ubiquitin-protein ligase MARCH5
, membrane-associated RING finger protein 5
, membrane-associated RING-CH protein V
, mitochondrial ubiquitin ligase
, ring finger protein 153