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Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase Proteins (MARCH6)

MARCH6 encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Additionally we are shipping MARCH6 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat MARCH6 MARCH6 294862  
MARCH6 223455 Q6ZQ89
MARCH6 10299 O60337
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Top MARCH6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MARCH6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase (MARCH6) Interaction Partners

Human Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase (MARCH6) interaction partners

  1. Loss of MARCH6 increases expression of SREBP-regulated genes involved in cholesterol biosynthesis and lipoprotein uptake.

  2. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (squalene monooxygenase (show SQLE Proteins); catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6.

  3. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

  4. analysis of yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4

  5. TEB4 interacts with and mediates loss of type 2 iodothyronine deiodinase (show DIO2 Proteins) (D2)activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 (show WSB1 Proteins) and TEB4 expression levels.

MARCH6 Protein Profile

Protein Summary

This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with MARCH6

  • membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6)
  • membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (MARCH6)
  • membrane-associated ring finger (C3HC4) 6 (march6)
  • membrane-associated ring finger (C3HC4) 6 (March6)
  • 3830408G03 protein
  • DOA10 protein
  • F830029L24Rik protein
  • im:7161807 protein
  • Mar-06 protein
  • MARCH-VI protein
  • mKIAA0597 protein
  • RGD1310927 protein
  • RGD1565757 protein
  • RNF176 protein
  • si:dkey-40c17.2 protein
  • TEB4 protein
  • wu:fa98a02 protein

Protein level used designations for MARCH6

E3 ubiquitin-protein ligase MARCH6 , fa98a02 , MARCH-VI , membrane-associated RING finger protein 6 , membrane-associated RING-CH protein VI , RING finger protein 176 , doa10 homolog , membrane-associated RING-CH finger protein 6

GENE ID SPECIES
294862 Rattus norvegicus
478617 Canis lupus familiaris
100002072 Danio rerio
420927 Gallus gallus
223455 Mus musculus
10299 Homo sapiens
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