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MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 184.108.40.206). Additionally we are shipping MARCH8 Proteins (6) and many more products for this protein.
Showing 10 out of 44 products:
Human Polyclonal MARCH8 Primary Antibody for EIA, IF - ABIN500234
Coscoy, Sanchez, Ganem: A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. in The Journal of cell biology 2001
Show all 4 references for ABIN500234
Chicken Polyclonal MARCH8 Primary Antibody for WB - ABIN2781250
Bernstein, Williams, Eisen, Mital, Wohlgemuth, Klingler, Fang, Deng, Kobashigawa: Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients. in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007
Human Polyclonal MARCH8 Primary Antibody for ELISA, WB - ABIN566949
Tada, Zhang, Koyama, Tobiume, Tsunetsugu-Yokota, Yamaoka, Fujita, Tokunaga: MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins. in Nature medicine 2015
March 8 functions in the embryo to modulate the strength of cell adhesion by regulating the localization of E-cadherin (show CDH1 Antibodies).
MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions.
MARCH 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.
MARCH8 protein localizes in lysosomes in HeLa cells
endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1.
MARCH8-mediated polyubiquitination and degradation of IL1RAP (show IL1RAP Antibodies) is an important mechanism for negative regulation of IL-1beta (show IL1B Antibodies)-induced signaling pathways.
MARCH8 expression led to direct ubiquitination of CD98 (show SLC3A2 Antibodies) and routing of CD98 (show SLC3A2 Antibodies) to late endosomes/lysosomes
Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV (show MARCH4 Antibodies) associate with Bap31 (show BCAP31 Antibodies) and target CD81 (show CD81 Antibodies) and CD44 (show CD44 Antibodies) to lysosomes
c-MIR induced specific down-regulation of B7-2 (show CD86 Antibodies) surface expression through ubiquitination, rapid endocytosis, and lysosomal degradation
Of the classifier's 11 informative genes, expression of MIR (show MLXIP Antibodies) and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection.
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003
E3 ubiquitin-protein ligase MARCH8
, c-mir, cellular modulator of immune recognition
, cellular modulator of immune recognition
, membrane-associated RING finger protein 8
, membrane-associated RING-CH protein VIII
, RING finger protein 178
, cellular modulator of immune recognition (c-MIR)