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anti-Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) Antibodies

MBTPS2 encodes a intramembrane zinc metalloprotease, which is essential in development. Additionally we are shipping MBTPS2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MBTPS2 51360 O43462
MBTPS2 270669 Q8CHX6
MBTPS2 302705  
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Top anti-MBTPS2 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB MBTPS2 Antibody (N-term) (ABIN656896) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with MBTPS2 Antibody (N-term) followed which  peroxidase conjugated to the secondary antibody and was followed by AB staining. Western blot analysis of MBTPS2 Antibody (N-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the MBTPS2 antibody detected the MBTPS2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of A549 cells, using MBTPS2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of MBTPS2 expression in HEK293T (A), Raw264.7 (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged MBTPS2 is 1 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to MBTPS2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, IF   100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

MBTPS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MBTPS2 Antibodies

  1. Human Polyclonal MBTPS2 Primary Antibody for EIA, IHC (p) - ABIN953342 : Ming, Happle, Grzeschik, Fischer: Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome due to mutation of the gene MBTPS2 in a large Australian kindred. in Pediatric dermatology 2009 (PubMed)
    Show all 5 references for ABIN953342

  2. Human Polyclonal MBTPS2 Primary Antibody for IHC (p), WB - ABIN656896 : Lee, Tirasophon, Shen, Michalak, Prywes, Okada, Yoshida, Mori, Kaufman: IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. in Genes & development 2002 (PubMed)

More Antibodies against MBTPS2 Interaction Partners

Human Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) interaction partners

  1. S2P is essential owing to its activation of the sterol regulatory element binding proteins (SREBPs); in the absence of exogenous lipid, cells lacking S2P cannot survive. (Review)

  2. In male patients, a genotype-phenotype correlation has begun to emerge, linking the site of the mutation in MBTPS2 with the clinical outcome described as IFAP syndrome.

  3. We demonstrate a novel association between an MBTPS2 mutation and an X-linked form of Olmsted syndrome.

  4. We report a fourth pedigree affected with Keratosis Follicularis Spinulosa Decalvans resulting from a recurrent missense mutation in the MBTPS2 gene.

  5. Both intronic MBTPS2 c.671-9T>G and c.225-6T>A point mutations are ichthyosis (show LBR Antibodies) follicularis, alopecia and photophobia syndrome causing mutations.

  6. We confirm that MBTPS2 mutations cause ichthyosis (show LBR Antibodies) follicularis atricia and photophobia syndrome in patients of Chinese origin

  7. Chinese family with a mild IFAP phenotype and a novel mutation in the MBTPS2 gene

  8. Missense mutations in the MBTPS2 gene have been identified as the cause of Follicularis Spinulosa Decalvans (KFSD (show SAT1 Antibodies)).

  9. S2P-mediated ATF6 (show ATF6 Antibodies) cleavage is involved in regulating XBP1 (show XBP1 Antibodies) in signaling the unfolded protein response.

  10. S2P cleavage is blocked by the bulky ATF6 (show ATF6 Antibodies) luminal domain, which is reduced in size by S1P (show MBTPS1 Antibodies)

Mouse (Murine) Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) interaction partners

  1. Data detected yy1 (show YY1 Antibodies), yy2 (show YY2 Antibodies), and mbtps2 mRNA in primary mouse neurons, microglia cells, and astrocytes. In comparison to yy2 (show YY2 Antibodies) and mbtps2, yy1 (show YY1 Antibodies) revealed the highest expression level in all cell types.

MBTPS2 Antigen Profile

Protein Summary

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome)\; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Gene names and symbols associated with MBTPS2

  • membrane-bound transcription factor peptidase, site 2 (MBTPS2) antibody
  • membrane-bound transcription factor peptidase, site 2 (Mbtps2) antibody
  • 9630032G22Rik antibody
  • AI662535 antibody
  • BRESEK antibody
  • IFAP antibody
  • KFSDX antibody
  • LRRGT00063 antibody
  • S2P antibody

Protein level used designations for MBTPS2

SREBPs intramembrane protease , endopeptidase S2P , membrane-bound transcription factor protease, site 2 , membrane-bound transcription factor site-2 protease , sterol regulatory element-binding proteins intramembrane protease , S2P endopeptidase , site-2 protease , Endopeptidase S2P , Sterol regulatory element-binding proteins intramembrane protease

GENE ID SPECIES
51360 Homo sapiens
270669 Mus musculus
302705 Rattus norvegicus
533134 Bos taurus
100454671 Pongo abelii
100689085 Cricetulus griseus
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