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Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) ELISA Kits

MBTPS2 encodes a intramembrane zinc metalloprotease, which is essential in development. Additionally we are shipping MBTPS2 Antibodies (33) and MBTPS2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human MBTPS2 MBTPS2 51360 O43462
Anti-Mouse MBTPS2 MBTPS2 270669 Q8CHX6
Anti-Rat MBTPS2 MBTPS2 302705  
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More ELISA Kits for MBTPS2 Interaction Partners

Human Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) interaction partners

  1. S2P is essential owing to its activation of the sterol regulatory element binding proteins (SREBPs); in the absence of exogenous lipid, cells lacking S2P cannot survive. (Review)

  2. In male patients, a genotype-phenotype correlation has begun to emerge, linking the site of the mutation in MBTPS2 with the clinical outcome described as IFAP syndrome.

  3. We demonstrate a novel association between an MBTPS2 mutation and an X-linked form of Olmsted syndrome.

  4. We report a fourth pedigree affected with Keratosis Follicularis Spinulosa Decalvans resulting from a recurrent missense mutation in the MBTPS2 gene.

  5. Both intronic MBTPS2 c.671-9T>G and c.225-6T>A point mutations are ichthyosis (show LBR ELISA Kits) follicularis, alopecia and photophobia syndrome causing mutations.

  6. We confirm that MBTPS2 mutations cause ichthyosis (show LBR ELISA Kits) follicularis atricia and photophobia syndrome in patients of Chinese origin

  7. Chinese family with a mild IFAP phenotype and a novel mutation in the MBTPS2 gene

  8. Missense mutations in the MBTPS2 gene have been identified as the cause of Follicularis Spinulosa Decalvans (KFSD (show SAT1 ELISA Kits)).

  9. S2P-mediated ATF6 (show ATF6 ELISA Kits) cleavage is involved in regulating XBP1 (show XBP1 ELISA Kits) in signaling the unfolded protein response.

  10. S2P cleavage is blocked by the bulky ATF6 (show ATF6 ELISA Kits) luminal domain, which is reduced in size by S1P (show MBTPS1 ELISA Kits)

Mouse (Murine) Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) interaction partners

  1. Data detected yy1 (show YY1 ELISA Kits), yy2 (show YY2 ELISA Kits), and mbtps2 mRNA in primary mouse neurons, microglia cells, and astrocytes. In comparison to yy2 (show YY2 ELISA Kits) and mbtps2, yy1 (show YY1 ELISA Kits) revealed the highest expression level in all cell types.

MBTPS2 Antigen Profile

Antigen Summary

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome)\; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Gene names and symbols associated with MBTPS2

  • membrane-bound transcription factor peptidase, site 2 (MBTPS2) antibody
  • membrane-bound transcription factor peptidase, site 2 (Mbtps2) antibody
  • 9630032G22Rik antibody
  • AI662535 antibody
  • BRESEK antibody
  • IFAP antibody
  • KFSDX antibody
  • LRRGT00063 antibody
  • S2P antibody

Protein level used designations for MBTPS2

SREBPs intramembrane protease , endopeptidase S2P , membrane-bound transcription factor protease, site 2 , membrane-bound transcription factor site-2 protease , sterol regulatory element-binding proteins intramembrane protease , S2P endopeptidase , site-2 protease , Endopeptidase S2P , Sterol regulatory element-binding proteins intramembrane protease

GENE ID SPECIES
51360 Homo sapiens
270669 Mus musculus
302705 Rattus norvegicus
533134 Bos taurus
100454671 Pongo abelii
100689085 Cricetulus griseus
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