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MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MARCH5 Proteins (4) and many more products for this protein.
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Cow (Bovine) Polyclonal MARCH5 Primary Antibody for WB - ABIN2774746
Karbowski, Neutzner, Youle: The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. in The Journal of cell biology 2007
Show all 2 references for 2774746
Human Polyclonal MARCH5 Primary Antibody for FACS, IHC (p) - ABIN651864
Yonashiro, Sugiura, Miyachi, Fukuda, Matsushita, Inatome, Ogata, Suzuki, Dohmae, Yanagi: Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. in Molecular biology of the cell 2009
MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after Viral hemorrhagic septicemia virus infection.
MARCH5 directly interacts with FUNDC1 (show FUNDC1 Antibodies) to mediate its ubiquitylation at lysine 119 for subsequent degradation.
These findings and data showing MARCH5-dependent degradation of MiD49 (show SMCR7 Antibodies) upon stress support the possibility that MARCH5 regulation of MiD49 (show SMCR7 Antibodies) is a novel mechanism controlling mitochondrial fission and, consequently, the cellular response to stress.
Self-clearance mechanism of mitochondrial ligase MARCH5 contributes to mitochondria quality control.MARCH5 is regulated by auto-ubiquitination.
MARCH5 binds MAVS (show MAVS Antibodies) only during viral stimulation when MAVS (show MAVS Antibodies) forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS (show MAVS Antibodies).
Our results indicate that HDAC6 (show HDAC6 Antibodies) is a critical regulator of MFN2 (show MFN2 Antibodies) degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress.
A fine balance of Mfn1 (show MFN1 Antibodies) levels is maintained by MARCH5-mediated quality control on acetylated Mfn1 (show MFN1 Antibodies).
MITOL regulates ER tethering to mitochondria by activating Mfn2 (show MFN2 Antibodies) via K192 ubiquitination.
balance between LC1 (show MAP1B Antibodies) activation by S-nitrosylation and down-regulation by MITOL is critical for neuronal cell survival
MARCH5 is an authentic E3 ubiquitin ligase (show MUL1 Antibodies) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 (show TLR7 Antibodies) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Antibodies).
study found that MITOL interacts with and ubiquitinates DeltaNAT-3Q71, a pathogenic ataxin-3 (show ATXN3 Antibodies) mutant, in mitochondria and attenuates its toxicity
These findings suggest that MITOL plays a protective role against apoptosis in cardiomyocytes.
March5 is involved in maintaining mouse-ESC (mESC) pluripotency via catalysis of Prkar1a (show PRKAR1A Antibodies) polyubiquitination and inhibition of the Raf (show RAF1 Antibodies)/MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) pathway.
Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway.
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006
membrane-associated ring finger (C3HC4) 5
, E3 ubiquitin-protein ligase MARCH5
, membrane-associated RING finger protein 5
, membrane-associated RING-CH protein V
, mitochondrial ubiquitin ligase
, ring finger protein 153