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MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 18.104.22.168). Additionally we are shipping MARCH8 Antibodies (46) and MARCH8 Proteins (7) and many more products for this protein.
Salmonella typhimurium SteD caused MARCH8-dependent ubiquitination and depletion of surface-localized mature MHC class II antigens.
YopJ mediates Ser- and Lys-acetylation and affects auto-ubiquitination of ubiquitin ligase MARCH8 in human cells.
Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins.
MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions.
MARCH 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.
MARCH8 protein localizes in lysosomes in HeLa cells
endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1.
MARCH8-mediated polyubiquitination and degradation of IL1RAP (show IL1RAP ELISA Kits) is an important mechanism for negative regulation of IL-1beta (show IL1B ELISA Kits)-induced signaling pathways.
MARCH8 expression led to direct ubiquitination of CD98 (show SLC3A2 ELISA Kits) and routing of CD98 (show SLC3A2 ELISA Kits) to late endosomes/lysosomes
Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV associate with Bap31 (show BCAP31 ELISA Kits) and target CD81 (show CD81 ELISA Kits) and CD44 (show CD44 ELISA Kits) to lysosomes
March 8 functions in the embryo to modulate the strength of cell adhesion by regulating the localization of E-cadherin (show CDH1 ELISA Kits).
orchestrated regulation of MHC II surface expression in thymic epithelial cells by MARCH 8 and CD83 (show CD83 ELISA Kits) plays a major role in CD4 (show CD4 ELISA Kits)(+) T cell selection.
CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection.
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003
E3 ubiquitin-protein ligase MARCH8
, RING finger protein 178
, c-mir, cellular modulator of immune recognition
, cellular modulator of immune recognition (c-MIR)
, membrane-associated RING finger protein 8
, membrane-associated RING-CH protein VIII
, cellular modulator of immune recognition
, membrane-associated ring finger (C3HC4) 8