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alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b. Additionally we are shipping Meprin A, alpha (PABA Peptide Hydrolase) Kits (14) and Meprin A, alpha (PABA Peptide Hydrolase) Proteins (10) and many more products for this protein.
Showing 10 out of 55 products:
Mouse (Murine) Polyclonal MEP1A Primary Antibody for ELISA, WB - ABIN2000231
Yura, Bradley, Ramesh, Reeves, Bond: Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge. in American journal of physiology. Renal physiology 2008
meprin alpha and meprin beta (show MEP1B Antibodies) join the modulators of Reelin (show RELN Antibodies) signalling as they cleave Reelin (show RELN Antibodies) at a specific site and are upregulated under specific pathological conditions.
While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B (show MEP1B Antibodies) cleaved all three PKA catalytic isoforms.
meprin alpha and meprin beta (show MEP1B Antibodies) are unique in their ability to process and release both C- and N-propeptides from type I procollagen (show COL1A2 Antibodies) in vitro and in vivo
the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock
Absence of meprin A aggravates chronic inflammation and lack of meprin B (show MEP1B Antibodies) affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.
meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE (show ACE Antibodies) inhibitor therapy
meprin A, a multimeric metalloprotease (show ADAMTS7 Antibodies) expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP (show BNC2 Antibodies) in the N terminus to mBNP7-32
meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.
MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.
Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin (show INS Antibodies) metabolism in overweight/obese central European women with polycystic ovary syndrome.
Meprin metalloproteases A and B inactivate interleukin 6 (show IL6 Antibodies)
Proteolytically active meprinalpha leads to an increase in EGFR (show EGFR Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) phosphorylation and subsequently enhances cell proliferation and migration
The present results indicate that a TNF-alpha (show TNF Antibodies)-mediated down-regulation of CDX2 (show CDX2 Antibodies) can be related to suppressed expression of MEP1A during intestinal inflammation.
Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.
Cystatin C (show CST3 Antibodies) was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta (show MEP1B Antibodies).
activation in colorectal cancer triggered by the plasminogen (show PLG Antibodies)-activating system
Mephrin beta induced a dramatic change in cell morphology and reduced the cell number, indicating a function in terminal differentiation, whereas meprin alpha did not affect cell viability, and may play a role in basal keratinocyte proliferation.
alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b
, endopeptidase-24.18 subunit alpha
, meprin A alpha
, meprin A subunit alpha
, meprin A alpha-subunit
, meprin alpha
, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
, PABA peptide hydrolase
, PPH alpha
, bA268F1.1 (meprin A alpha (PABA peptide hydrolase))