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Meprin A, alpha (PABA Peptide Hydrolase) Proteins (MEP1A)

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b [RGD, Feb 2006].. Additionally we are shipping Meprin A, alpha (PABA Peptide Hydrolase) Antibodies (55) and Meprin A, alpha (PABA Peptide Hydrolase) Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat MEP1A MEP1A 25684 Q64230
MEP1A 17287 P28825
MEP1A 4224 Q16819
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Top Meprin A, alpha (PABA Peptide Hydrolase) Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$950.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,125.10
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

MEP1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , ,
, ,

Top referenced Meprin A, alpha (PABA Peptide Hydrolase) Proteins

  1. Mouse (Murine) MEP1A Protein expressed in Human Cells - ABIN2007239 : Yura, Bradley, Ramesh, Reeves, Bond: Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge. in American journal of physiology. Renal physiology 2008 (PubMed)

More Proteins for Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaction Partners

Mouse (Murine) Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) interaction partners

  1. meprin alpha and meprin beta (show MEP1B Proteins) join the modulators of Reelin (show RELN Proteins) signalling as they cleave Reelin (show RELN Proteins) at a specific site and are upregulated under specific pathological conditions.

  2. While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B (show MEP1B Proteins) cleaved all three PKA catalytic isoforms.

  3. meprin alpha and meprin beta (show MEP1B Proteins) are unique in their ability to process and release both C- and N-propeptides from type I procollagen (show COL1A2 Proteins) in vitro and in vivo

  4. the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock

  5. Absence of meprin A aggravates chronic inflammation and lack of meprin B (show MEP1B Proteins) affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.

  6. meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE (show ACE Proteins) inhibitor therapy

  7. meprin A, a multimeric metalloprotease expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP in the N terminus to mBNP7-32

  8. meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.

  9. MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

Human Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) interaction partners

  1. Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin (show INS Proteins) metabolism in overweight/obese central European women with polycystic ovary syndrome.

  2. Meprin metalloproteases A and B inactivate interleukin 6 (show IL6 Proteins)

  3. Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration

  4. The present results indicate that a TNF-alpha (show TNF Proteins)-mediated down-regulation of CDX2 (show CDX2 Proteins) can be related to suppressed expression of MEP1A during intestinal inflammation.

  5. Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.

  6. Cystatin C (show CST3 Proteins) was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta (show MEP1B Proteins).

  7. activation in colorectal cancer triggered by the plasminogen (show PLG Proteins)-activating system

  8. Mephrin beta induced a dramatic change in cell morphology and reduced the cell number, indicating a function in terminal differentiation, whereas meprin alpha did not affect cell viability, and may play a role in basal keratinocyte proliferation.

  9. MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Protein Profile

Protein Summary

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b

Gene names and symbols associated with MEP1A

  • meprin 1 alpha (Mep1a)
  • meprin A, alpha (PABA peptide hydrolase) (MEP1A)
  • AI098089 protein
  • AW107200 protein
  • Mep-1 protein
  • Mep-1a protein
  • Mep1 protein
  • PPHA protein

Protein level used designations for MEP1A

E-24.18 , MEP-1 , endopeptidase-2 , endopeptidase-24.18 subunit alpha , meprin A alpha , meprin A subunit alpha , meprin A alpha-subunit , meprin alpha , N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha , PABA peptide hydrolase , PPH alpha , bA268F1.1 (meprin A alpha (PABA peptide hydrolase))

GENE ID SPECIES
25684 Rattus norvegicus
17287 Mus musculus
4224 Homo sapiens
481826 Canis lupus familiaris
100154136 Sus scrofa
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