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Mesencephalic Astrocyte-Derived Neurotrophic Factor Proteins (MANF)

The protein encoded by MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Additionally we are shipping MANF Antibodies (92) and MANF Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MANF 7873 P55145
MANF 74840  
MANF 315989  
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Top MANF Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$313.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details

MANF Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced MANF Proteins

  1. Human MANF Protein expressed in Human Cells - ABIN2004225 : Shridhar, Rivard, Shridhar, Mullins, Bostick, Sakr, Grignon, Miller, Smith: A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. in Oncogene 1996 (PubMed)
    Show all 3 references for ABIN2004225

  2. Mouse (Murine) MANF Protein expressed in Human Cells - ABIN2008442 : Gevaert, Goethals, Martens, Van Damme, Staes, Thomas, Vandekerckhove: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. in Nature biotechnology 2003 (PubMed)
    Show all 3 references for ABIN2008442

  3. Human MANF Protein expressed in Escherichia coli (E. coli) - ABIN1098235 : Petrova, Raibekas, Pevsner, Vigo, Anafi, Moore, Peaire, Shridhar, Smith, Kelly, Durocher, Commissiong: MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. in Journal of molecular neuroscience : MN 2003 (PubMed)
    Show all 2 references for ABIN1098235

More Proteins for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaction Partners

Fruit Fly (Drosophila melanogaster) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.

  2. DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.

  3. study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF (show CDNF Proteins) proteins and reveals the importance of the C-terminal domain for MANF activity in vivo

  4. role of MANF in multicellular organism development

  5. DmMANF is an invertebrate neurotrophic factor (show NTF3 Proteins) supporting dopaminergic neurons.

Zebrafish Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.

Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.

  2. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.

  3. MANF is a protein that interacts with RTN1-C (show RTN1 Proteins)

  4. We demonstrate that Armet and Creld2 (show CRELD2 Proteins) are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 (show MATN3 Proteins) is a key disease trigger in MED that could be exploited as a potential therapeutic target

  5. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.

  6. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

  7. Pretreatment with adeno (show ADORA2A Proteins)-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.

  8. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response.

  9. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

  10. structures of MANF and CDNF (show CDNF Proteins) were solved; structure explains why MANF and CDNF (show CDNF Proteins) are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain

Mouse (Murine) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) interaction partners

  1. MANF has immune modulatory properties that are required for retinal repair in Drosophila

  2. secretion of mouse MANF and mouse CDNF (show CDNF Proteins) is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF (show CDNF Proteins) among species might influence their intracellular functions.

  3. MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.

  4. Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78 (show HSPA5 Proteins).

  5. The change in Armet expression lasted while the change of Mrpl51 (show MRPL51 Proteins) disappeared after birth.

  6. the solution structure of ARMET

  7. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum

  8. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

MANF Protein Profile

Protein Summary

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

Gene names and symbols associated with MANF

  • mesencephalic astrocyte-derived neurotrophic factor (MANF)
  • Mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • mesencephalic astrocyte-derived neurotrophic factor (manf)
  • mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • 3230402M22Rik protein
  • AA407711 protein
  • AA408789 protein
  • AA673178 protein
  • anon-EST:ParkEST188 protein
  • Armet protein
  • ARP protein
  • ARP-like protein
  • CG7013 protein
  • D18Mgi17 protein
  • D17914 protein
  • Dmel\\CG7013 protein
  • DmMANF protein
  • im:6909481 protein
  • MANF protein
  • RBM15B protein
  • zgc:153327 protein

Protein level used designations for MANF

mesencephalic astrocyte-derived neurotrophic factor , arginine-rich, mutated in early stage tumors , CG7013-PA , Manf-PA , ARP-like , arginine-rich protein , RNA binding motif protein 15B , chromosome 3p21.1 gene sequence

GENE ID SPECIES
745542 Pan troglodytes
41983 Drosophila melanogaster
549179 Xenopus (Silurana) tropicalis
767691 Danio rerio
7873 Homo sapiens
608421 Canis lupus familiaris
74840 Mus musculus
315989 Rattus norvegicus
540432 Bos taurus
100505460 Sus scrofa
770664 Gallus gallus
100719906 Cavia porcellus
Selected quality suppliers for MANF Proteins (MANF)
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