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Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Additionally we are shipping MESDC2 Antibodies (38) and MESDC2 Kits (6) and many more products for this protein.
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Human MESDC2 Protein expressed in Human Cells - ABIN2003646
Koduri, Blacklow: Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. in Biochemistry 2007
Show all 3 references for ABIN2003646
Human MESDC2 Protein expressed in Escherichia coli (E. coli) - ABIN667879
Köhler, Andersen, Diehl, Krause, Schmieder, Oschkinat: The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. in Journal of structural and functional genomics 2007
Show all 2 references for ABIN667879
Mesd C-terminal region constitutes the major LRP5 (show LRP5 Proteins)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer
Results indicate that Mesd is a universal inhibitor of Wnt (show WNT2 Proteins)/LRP (show RPSA Proteins) signaling on the cell surface.
Results provide evidence that MESD functions as a general LRP (show RPSA Proteins) chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP (show RPSA Proteins) receptors.
Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6 (show LRP5 Proteins).
a high bone mass mutant LRP5 (show LRP5 Proteins)(G171V), has subtly reduced Dkk1 (show DKK1 Proteins) binding, and, in contrast to LRP5 (show LRP5 Proteins), no enhancement of binding with MesD
as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 (show SENP1 Proteins) gene (SENP1 (show SENP1 Proteins)) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused
Mesd and LRP6 (show LRP6 Proteins) modulate Wnt (show WNT2 Proteins) signaling.
Mescd2 binds to Lrp4 (show CORIN Proteins) and regulates Lrp4 (show CORIN Proteins) surface expression in myotubes.
The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone (show HSP90AA1 Proteins) for the low-density lipoprotein receptor (LDLR (show LDLR Proteins)) family.
We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6 (show LRP6 Proteins). Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6 (show LRP6 Proteins).
Functional analyses of the Lrp6 (show LRP6 Proteins) rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6 (show LRP6 Proteins), leading to impaired Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets.
Mesd not only blocks binding of Dickkopf (show DKK1 Proteins) (DKK)-1 (show DKK1 Proteins) and sclerostin (show SOST Proteins) proteins to low-density lipoprotein receptor (show LDLR Proteins)-related protein (LRP (show LRP1 Proteins))5 (show LRP5 Proteins) and LRP6 (show LRP6 Proteins) but also inhibits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in LRP5 (show LRP5 Proteins)- or LRP6 (show LRP6 Proteins)- expressing cancer cells.
Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6 (show LRP6 Proteins).
Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).
mesoderm development candidate 2
, Mesoderm development candidate 2
, LDLR chaperone MESD
, mesoderm development protein
, renal carcinoma antigen NY-REN-61
, mesoderm development candiate 2