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Mesoderm Development Candidate 2 Proteins (MESDC2)

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Additionally we are shipping MESDC2 Antibodies (37) and MESDC2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MESDC2 23184 Q14696
MESDC2 67943 Q9ERE7
Rat MESDC2 MESDC2 308796 Q5U2R7
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Top MESDC2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,429.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,489.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Escherichia coli (E. coli) Human His tag   2 μg Log in to see 6 to 11 Days
$142.86
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

MESDC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced MESDC2 Proteins

  1. Human MESDC2 Protein expressed in Human Cells - ABIN2003646 : Koduri, Blacklow: Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. in Biochemistry 2007 (PubMed)
    Show all 3 references for ABIN2003646

  2. Human MESDC2 Protein expressed in Escherichia coli (E. coli) - ABIN667879 : Köhler, Andersen, Diehl, Krause, Schmieder, Oschkinat: The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. in Journal of structural and functional genomics 2007 (PubMed)
    Show all 2 references for ABIN667879

More Proteins for Mesoderm Development Candidate 2 (MESDC2) Interaction Partners

Human Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mesd C-terminal region constitutes the major LRP5 (show LRP5 Proteins)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  2. Results indicate that Mesd is a universal inhibitor of Wnt (show WNT2 Proteins)/LRP (show RPSA Proteins) signaling on the cell surface.

  3. Results provide evidence that MESD functions as a general LRP (show RPSA Proteins) chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP (show RPSA Proteins) receptors.

  4. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6 (show LRP5 Proteins).

  5. a high bone mass mutant LRP5 (show LRP5 Proteins)(G171V), has subtly reduced Dkk1 (show DKK1 Proteins) binding, and, in contrast to LRP5 (show LRP5 Proteins), no enhancement of binding with MesD

  6. as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 (show SENP1 Proteins) gene (SENP1 (show SENP1 Proteins)) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused

  7. Mesd and LRP6 (show LRP6 Proteins) modulate Wnt (show WNT2 Proteins) signaling.

Mouse (Murine) Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mescd2 binds to Lrp4 (show CORIN Proteins) and regulates Lrp4 (show CORIN Proteins) surface expression in myotubes.

  2. Mesd C-terminal region constitutes the major LRP5 (show LRP5 Proteins)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  3. The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone (show HSP90AA1 Proteins) for the low-density lipoprotein receptor (LDLR (show LDLR Proteins)) family.

  4. We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6 (show LRP6 Proteins). Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6 (show LRP6 Proteins).

  5. Functional analyses of the Lrp6 (show LRP6 Proteins) rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6 (show LRP6 Proteins), leading to impaired Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling

  6. Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets.

  7. Mesd not only blocks binding of Dickkopf (show DKK1 Proteins) (DKK)-1 (show DKK1 Proteins) and sclerostin (show SOST Proteins) proteins to low-density lipoprotein receptor (show LDLR Proteins)-related protein (LRP (show LRP1 Proteins))5 (show LRP5 Proteins) and LRP6 (show LRP6 Proteins) but also inhibits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in LRP5 (show LRP5 Proteins)- or LRP6 (show LRP6 Proteins)- expressing cancer cells.

  8. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6 (show LRP6 Proteins).

MESDC2 Protein Profile

Protein Summary

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).

Gene names and symbols associated with MESDC2

  • mesoderm development candidate 2 (MESDC2)
  • mesoderm development candidate 2 (mesdc2)
  • mesoderm development candidate 2 (CpipJ_CPIJ010816)
  • mesoderm development candidate 2 (Tsp_04045)
  • Mesoderm development candidate 2 (LOC100157638)
  • KIAA1199 (KIAA1199)
  • mesoderm development candidate 2 (Mesdc2)
  • 2210015O11Rik protein
  • AW537813 protein
  • BOCA protein
  • mesd protein
  • MESDC2 protein
  • MGC115616 protein
  • mKIAA0081 protein
  • msd protein
  • zgc:158636 protein

Protein level used designations for MESDC2

mesoderm development candidate 2 , Mesoderm development candidate 2 , LDLR chaperone MESD , mesoderm development protein , renal carcinoma antigen NY-REN-61 , mesoderm development candiate 2

GENE ID SPECIES
453586 Pan troglodytes
488765 Canis lupus familiaris
712993 Macaca mulatta
734603 Xenopus laevis
6043369 Culex quinquefasciatus
10904464 Trichinella spiralis
100135217 Xenopus (Silurana) tropicalis
100157638 Sus scrofa
100174652 Pongo abelii
23184 Homo sapiens
67943 Mus musculus
308796 Rattus norvegicus
514610 Bos taurus
415475 Gallus gallus
791222 Danio rerio
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