You are viewing an incomplete version of our website. Please click to reload the website as full version.

Mesoderm Posterior 2 Homolog (Mouse) Proteins (Mesp2)

Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. Additionally we are shipping Mesp2 Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mesp2 17293 O08574
Rat Mesp2 Mesp2 293046  
Mesp2 145873 Q0VG99
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Mesp2 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

Mesp2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) Interaction Partners

Mouse (Murine) Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

  1. Studies indicate that mesodermal posterior 1 (Mesp1 (show MESP1 Proteins)) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.

  2. conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively

  3. current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton

  4. Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (show NOTCH1 Proteins) target genes.

  5. Data propose a novel function of Notch (show NOTCH1 Proteins) signaling, in which a progressive oscillating wave of Notch (show NOTCH1 Proteins) activity is translated into the rostral-caudal polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.

  6. A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.

  7. Data describe the genetic interactions between Dll1 (show DLL1 Proteins), Dll3 (show DLL3 Proteins), Mesp2 and Psen1 (show PSEN1 Proteins), and the roles of Dll1 (show DLL1 Proteins)- and Dll3 (show DLL3 Proteins)-Notch (show NOTCH1 Proteins) pathways, with or without Psen1 (show PSEN1 Proteins), in rostrocaudal patterning.

  8. Mesp2 is responsible for the rostro-caudal patterning process itself in the anterior presomitic mesoderm, via cellular interaction.

  9. developmental protein "wavefront" is generated by suppression of Notch (show NOTCH1 Proteins) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (show LFNG Proteins) gene (Lfng (show LFNG Proteins))

  10. Tbx6 (show TBX6 Proteins) directly binds to the Mesp2 gene upstream region and mediates Notch (show NOTCH1 Proteins) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.

Human Mesoderm Posterior 2 Homolog (Mouse) (Mesp2) interaction partners

  1. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.

  2. Mutated MESP2 causes spondylocostal dysostosis

  3. Mesp1 (show MESP1 Proteins) is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.

  4. findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome

Mesp2 Protein Profile

Protein Summary

This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).

Gene names and symbols associated with Mesp2

  • mesoderm posterior 2 (MESP2)
  • mesoderm posterior 2 (Mesp2)
  • mesoderm posterior 2 homolog (mouse) (Mesp2)
  • mesoderm posterior 2 homolog (mouse) (MESP2)
  • bHLHc6 protein
  • SCDO2 protein

Protein level used designations for Mesp2

mesoderm posterior 2 , mesoderm posterior protein 2 , class C basic helix-loop-helix protein 6

GENE ID SPECIES
100015370 Monodelphis domestica
17293 Mus musculus
293046 Rattus norvegicus
145873 Homo sapiens
Selected quality suppliers for Mesp2 Proteins (Mesp2)
Did you look for something else?