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Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. Additionally we are shipping Mesp2 Proteins (2) and many more products for this protein.
Showing 10 out of 35 products:
Mouse (Murine) Polyclonal Mesp2 Primary Antibody for WB - ABIN2779870
Morimoto, Takahashi, Endo, Saga: The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. in Nature 2005
Show all 2 references for 2779870
Human Monoclonal Mesp2 Primary Antibody for ELISA, WB - ABIN1098148
Qiu, Zhou, Jiang, Ji, Ding, Lv, Liu, Tang, Cheng, Qiu: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis. in Studies in health technology and informatics 2012
Show all 2 references for 1098148
Studies indicate that mesodermal posterior 1 (Mesp1 (show MESP1 Antibodies)) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal (show CAD Antibodies) properties, respectively
current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (show NOTCH1 Antibodies) target genes.
Data propose a novel function of Notch (show NOTCH1 Antibodies) signaling, in which a progressive oscillating wave of Notch (show NOTCH1 Antibodies) activity is translated into the rostral-caudal (show CAD Antibodies) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.
Data describe the genetic interactions between Dll1 (show DLL1 Antibodies), Dll3 (show DLL3 Antibodies), Mesp2 and Psen1 (show PSEN1 Antibodies), and the roles of Dll1 (show DLL1 Antibodies)- and Dll3 (show DLL3 Antibodies)-Notch (show NOTCH1 Antibodies) pathways, with or without Psen1 (show PSEN1 Antibodies), in rostrocaudal patterning.
Mesp2 is responsible for the rostro-caudal (show CAD Antibodies) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.
developmental protein "wavefront" is generated by suppression of Notch (show NOTCH1 Antibodies) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (show LFNG Antibodies) gene (Lfng (show LFNG Antibodies))
Tbx6 (show TBX6 Antibodies) directly binds to the Mesp2 gene upstream region and mediates Notch (show NOTCH1 Antibodies) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Mutated MESP2 causes spondylocostal dysostosis
Mesp1 (show MESP1 Antibodies) is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
mesoderm posterior 2
, mesoderm posterior protein 2
, class C basic helix-loop-helix protein 6