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Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. Additionally we are shipping Mesp2 Antibodies (35) and Mesp2 Proteins (2) and many more products for this protein.
Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
conclusion was supported by analyses of Mesp2 KO and Ripply1 (show RIPPLY1 ELISA Kits)/2 double KO embryos lacking rostral and caudal (show CAD ELISA Kits) properties, respectively
current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (show NOTCH1 ELISA Kits) target genes.
Data propose a novel function of Notch (show NOTCH1 ELISA Kits) signaling, in which a progressive oscillating wave of Notch (show NOTCH1 ELISA Kits) activity is translated into the rostral-caudal (show CAD ELISA Kits) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.
Data describe the genetic interactions between Dll1 (show DLL1 ELISA Kits), Dll3 (show DLL3 ELISA Kits), Mesp2 and Psen1 (show PSEN1 ELISA Kits), and the roles of Dll1 (show DLL1 ELISA Kits)- and Dll3 (show DLL3 ELISA Kits)-Notch (show NOTCH1 ELISA Kits) pathways, with or without Psen1 (show PSEN1 ELISA Kits), in rostrocaudal patterning.
Mesp2 is responsible for the rostro-caudal (show CAD ELISA Kits) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.
developmental protein "wavefront" is generated by suppression of Notch (show NOTCH1 ELISA Kits) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (show LFNG ELISA Kits) gene (Lfng (show LFNG ELISA Kits))
Tbx6 (show TBX6 ELISA Kits) directly binds to the Mesp2 gene upstream region and mediates Notch (show NOTCH1 ELISA Kits) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Mutated MESP2 causes spondylocostal dysostosis
Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
mesoderm posterior 2
, mesoderm posterior protein 2
, class C basic helix-loop-helix protein 6