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MEST encodes a member of the alpha/beta hydrolase superfamily. Additionally we are shipping MEST Kits (5) and MEST Proteins (4) and many more products for this protein.
Showing 10 out of 26 products:
Mouse (Murine) Polyclonal MEST Primary Antibody for ELISA, WB - ABIN4333916
Li, Vu, Lee, Yang, Nguyen, Bui, Zeng, Nguyen, Hu, Murphy, Jirtle, Hoffman: An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. in The Journal of biological chemistry 2002
diet-induced ATE in MEST-deficient mice diminishes hypoxia and inflammation in WAT leading to improved glucose tolerance and insulin (show INS Antibodies) sensitivity
The androgenetic patterns of H19 (show NCKAP1 Antibodies), Snrpn (show SNRPN Antibodies), and Mest were maintained even after differentiation of germline-derived pluripotent stem cells(gPS (show NBEAL2 Antibodies)) into neural stem cells(NSC), whereas the fully unmethylated status of Ndn (show NDN Antibodies) in SSCs was altered to somatic patterns in gPS (show NBEAL2 Antibodies) cells and gPS (show NBEAL2 Antibodies)-NSCs.
The balance of factors controlling fat deposition can be evaluated in part by the differential expression profiles of Mest and Sfrp5 (show SFRP5 Antibodies) genes with functions linked to fat deposition as long as there is an active accumulation of fat mass.
the expression of Mest and Sfrp5 (show SFRP5 Antibodies) were tightly associated across the 5 mouse strains with the highest and lowest expression occurring in DBA (show RPS19 Antibodies)/2J and C57BL/6J (B6) respectively suggesting a common mechanism for their regulation.
Although both Mest and miR (show MLXIP Antibodies)-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth.
The paternally expressed imprinted gene Mest was only detected in haploid androgenetic blastocysts and was significantly lower in this group relative to the controls, indicating that the gene maintains expression patterns specific to its parental origin.
analysis of modifications of H3 histone (show HIST1H3B Antibodies) in H19 (show NCKAP1 Antibodies) and MEST imprinted genes in blastocysts produced in vitro from non-vitrified and vitrified two-cell embryos
Results suggest that at least one allele of Mest expression is required in the somatic tissues of adult individuals and that under certain conditions (such as in the presence of a Mest insertional mutation or in an altered genetic background), somatically acquired alterations of allelic expression at the Mest locus may occur.
The data showed that Mest expression was regulated through cAMP-dependent protein kinase A pathways during differentiation of preadipocytes into adipocytes in vitro, supporting the critical role of Mest in proliferation and differentiation of adipocytes.
The identification of new imprinted RNA products at the Mest locus, longer variants of the RNA, called MestXL, transcribed >10 kb into the downstream antisense gene Copg2 (show COPG2 Antibodies).
Some growth-regulating imprinted genes such as MEST and MEG3 (show FAM129B Antibodies), are susceptible to non-imprinted allele during development and differentiation, whereas the intergenic differentially methylated region of others (i.e. PEG3 (show PEG3 Antibodies)) are strictly maintained.
G4 formation at motifs not previously identified through bioinformatic analysis of the MEST promoter, is reported.
altered DNA methylation (show HELLS Antibodies) at imprinted domains including IGF2/H19 (show NCKAP1 Antibodies) and PEG1/MEST may mediate the association between human papillomavirus infection and invasive cervical cancer
The expression levels of miR (show MLXIP Antibodies)-335 significantly correlated with those of MEST, supporting the notion that the intronic miR (show MLXIP Antibodies)-335 is co-expressed with its host gene
DNA methylation (show HELLS Antibodies) level at the H19 (show NCKAP1 Antibodies) and MEST differentially methylated regions (DMRs)is reduced in placentas from pregnancies conceived by IVF (show SCN5A Antibodies)/ICSI when compared with placentas from spontaneous conception.
Paternal methylation aberrations at imprinting control regions of DLK1 (show DLK1 Antibodies)-GTL2, MEST (PEG1), and ZAC (PLAGL1 (show PLAGL1 Antibodies)) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages.
Data indicate that ARMCX2 (show ARMCX2 Antibodies), COL1A1 (show COL1A1 Antibodies), MDK (show MDK Antibodies), MEST and MLH1 (show MLH1 Antibodies) genes acquired methylation in drug-resistant ovarian cancer-sustaining (side population) cells.
MEST showed tissue-specific imprinting, being paternally expressed in skeletal muscle, fat, pituitary gland, heart, kidney, lung, stomach and uterus, and maternally expressed in spleen and liver.
In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes.
Regardless of conception method, the PEG1 methylation percentage in chorionic villus from spontaneous abortions is significantly higher than in villus from induced abortions and multifetal reduction.
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.
mesoderm-specific transcript protein
, paternally-expressed gene 1 protein
, mesoderm specific transcript homolog
, mesoderm-specific transcript homolog protein