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human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis. Additionally we are shipping Metadherin Antibodies (76) and Metadherin Proteins (8) and many more products for this protein.
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AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A ELISA Kits) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB ELISA Kits)/AEG-1/c-Myc (show MYC ELISA Kits) mice that was not observed when either AEG-1 or c-Myc (show MYC ELISA Kits) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B ELISA Kits)- or TNF-alpha (show TNF ELISA Kits)-induced AEG-1 interaction with NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 ELISA Kits).
oncogene (show RAB1A ELISA Kits) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF ELISA Kits) superfamily member TRAIL (Tumor Necrosis Factor (show TNF ELISA Kits)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 ELISA Kits).
Data showed that AEG1 and MMP7 (show MMP7 ELISA Kits) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 ELISA Kits)-p42/p44 (show PSMC6 ELISA Kits)-dependent activation of MMP7 (show MMP7 ELISA Kits).
Results indicate that microRNA miR (show MLXIP ELISA Kits)-497 directly inhibited the 3'-untranslated regions (3' UTRs) of vascular endothelial growth factor A (VEGFA (show VEGFA ELISA Kits)) and astrocyte elevated gene-1 (AEG-1).
High AEG-1 staining index might be associated with tumor progression and poor survival status in patients with gastrointestinal cancer. Meta-analysis.
miR (show MLXIP ELISA Kits)-302c-3p play a pivotal role in the progression of glioma by targeting MTDH and is a potential inhibitor in glioma treatment.
Identify two novel factors, AKR1C2 (show AKR1C2 ELISA Kits) (positive factor) and NF1 (show NF1 ELISA Kits) (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer.
Knockdown of MTDH inhibits phosphorylation of AKT (show AKT1 ELISA Kits) and increased apoptosis related protein expression.
EFEMP1 (show FBLN3 ELISA Kits) might indirectly enhance the expression of MMP-2 (show MMP2 ELISA Kits), providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB (show NFKB1 ELISA Kits) pathways might be one of the effective ways which EFEMP1 (show FBLN3 ELISA Kits) was induced by AEG-1.
AEG-1 mediates CCL3 (show CCL3 ELISA Kits)/CCR5 (show CCR5 ELISA Kits)-induced EMT (show ITK ELISA Kits) development via both Erk1/2 (show MAPK1/3 ELISA Kits) and Akt (show AKT1 ELISA Kits) signaling pathway in CM patients, which indicates CCL3 (show CCL3 ELISA Kits)/CCR5 (show CCR5 ELISA Kits)-AEG-1-EMT (show ITK ELISA Kits) pathway could be suggested as a useful target to affect the progression of CM.
Data established that AEG-1 is frequently upregulated and functions as an oncogene (show RAB1A ELISA Kits) by regulating several major signaling pathways in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) suggesting potential role as a biomarker or target for HCC (show FAM126A ELISA Kits) therapy. [review]
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein