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human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis. Additionally we are shipping Metadherin Antibodies (96) and Metadherin Proteins (8) and many more products for this protein.
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AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A ELISA Kits) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB ELISA Kits)/AEG-1/c-Myc (show MYC ELISA Kits) mice that was not observed when either AEG-1 or c-Myc (show MYC ELISA Kits) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B ELISA Kits)- or TNF-alpha (show TNF ELISA Kits)-induced AEG-1 interaction with NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 ELISA Kits).
oncogene (show RAB1A ELISA Kits) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF ELISA Kits) superfamily member TRAIL (Tumor Necrosis Factor (show TNF ELISA Kits)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
Our results suggest that underexpression of miR (show MLXIP ELISA Kits)-30a-5p might function as a tumor suppressing miRNA by directly targeting MTDH in HCC (show FAM126A ELISA Kits) and is therefore a potential candidate biomarker for HCC (show FAM126A ELISA Kits) targeting therapy.
MiR (show MLXIP ELISA Kits)-136 plays a key role in temozolomide (TMZ) resistance by targeting AEG-1 in glioma cell line, suggesting that miR (show MLXIP ELISA Kits)-136 can be used to predict a patient's response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.
Data indicate metadherin (MTDH) as a direct target gene of microRNA miR (show MLXIP ELISA Kits)-630.
AEG-1 overexpression is closely associated with epithelial-mesenchymal transition and promote metastasis in tongue squamous cell carcinoma.
MiR (show MLXIP ELISA Kits)-30a-5p may play an essential role in the cell growth and apoptosis of hepatocellular carcinoma cells, partially via targeting AEG-1.
Suggest that miR (show MLXIP ELISA Kits)-377 plays an important role in the development of NSCLC by regulating AEG-1 expression.
High MTDH expression is associated with multiple myeloma.
In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 ELISA Kits).
Data showed that AEG1 and MMP7 (show MMP7 ELISA Kits) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 ELISA Kits)-p42/p44 (show PSMC6 ELISA Kits)-dependent activation of MMP7 (show MMP7 ELISA Kits).
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein