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Metadherin Proteins (MTDH)

human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis [RGD, Feb 2006].. Additionally we are shipping Metadherin Antibodies (94) and Metadherin Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTDH 67154 Q80WJ7
Rat MTDH MTDH 170910 Q9Z1W6
MTDH 92140 Q86UE4
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Top Metadherin Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag,GST tag 50 μg Log in to see 16 Days
$551.25
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MTDH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , , , ,
, , ,

More Proteins for Metadherin (MTDH) Interaction Partners

Mouse (Murine) Metadherin (MTDH) interaction partners

  1. AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.

  2. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.

  3. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis

  4. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.

  5. RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed

  6. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.

  7. IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.

  8. MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).

  9. oncogene (show RAB1A Proteins) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Proteins) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Proteins)-related Apoptosis-inducing Ligand) in breast cancer

  10. The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.

Human Metadherin (MTDH) interaction partners

  1. High MTDH expression is associated with multiple myeloma.

  2. In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.

  3. We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 Proteins).

  4. Data showed that AEG1 and MMP7 (show MMP7 Proteins) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 Proteins)-p42/p44 (show PSMC6 Proteins)-dependent activation of MMP7 (show MMP7 Proteins).

  5. Results indicate that microRNA miR (show MLXIP Proteins)-497 directly inhibited the 3'-untranslated regions (3' UTRs) of vascular endothelial growth factor A (VEGFA (show VEGFA Proteins)) and astrocyte elevated gene-1 (AEG-1).

  6. High AEG-1 staining index might be associated with tumor progression and poor survival status in patients with gastrointestinal cancer. Meta-analysis.

  7. miR (show MLXIP Proteins)-302c-3p play a pivotal role in the progression of glioma by targeting MTDH and is a potential inhibitor in glioma treatment.

  8. Identify two novel factors, AKR1C2 (show AKR1C2 Proteins) (positive factor) and NF1 (show NF1 Proteins) (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer.

  9. Knockdown of MTDH inhibits phosphorylation of AKT (show AKT1 Proteins) and increased apoptosis related protein expression.

  10. EFEMP1 (show FBLN3 Proteins) might indirectly enhance the expression of MMP-2 (show MMP2 Proteins), providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB (show NFKB1 Proteins) pathways might be one of the effective ways which EFEMP1 (show FBLN3 Proteins) was induced by AEG-1.

Metadherin (MTDH) Protein Profile

Protein Summary

human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis

Gene names and symbols associated with Metadherin Proteins (MTDH)

  • metadherin (mtdh)
  • metadherin (MTDH)
  • metadherin (Mtdh)
  • 3D3 protein
  • 3D3/Lyric protein
  • 2610103J23Rik protein
  • AEG-1 protein
  • AEG1 protein
  • AV353288 protein
  • D8Bwg1112e protein
  • LYRIC protein
  • LYRIC/3D3 protein
  • MGC75963 protein

Protein level used designations for Metadherin Proteins (MTDH)

metadherin , LYRIC/3D3 , protein LYRIC , protein LYRIC-like , lysine-rich CEACAM1 co-isolated protein , metastasis adhesion protein , LYRIC , 3D3/LYRIC , astrocyte elevated gene-1 protein

GENE ID SPECIES
394771 Xenopus (Silurana) tropicalis
420239 Gallus gallus
472825 Pan troglodytes
509788 Bos taurus
612147 Canis lupus familiaris
702410 Macaca mulatta
100059885 Equus caballus
100153168 Sus scrofa
100385408 Callithrix jacchus
100444491 Pongo abelii
100579266 Nomascus leucogenys
67154 Mus musculus
170910 Rattus norvegicus
92140 Homo sapiens
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