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human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis [RGD, Feb 2006].. Additionally we are shipping Metadherin Antibodies (76) and Metadherin Kits (7) and many more products for this protein.
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AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).
oncogene (show RAB1A Proteins) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Proteins) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Proteins)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2 (show AKR1C2 Proteins).
Data showed that AEG1 and MMP7 (show MMP7 Proteins) levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK (show MAPK1 Proteins)-p42/p44 (show PSMC6 Proteins)-dependent activation of MMP7 (show MMP7 Proteins).
Results indicate that microRNA miR (show MLXIP Proteins)-497 directly inhibited the 3'-untranslated regions (3' UTRs) of vascular endothelial growth factor A (VEGFA (show VEGFA Proteins)) and astrocyte elevated gene-1 (AEG-1).
High AEG-1 staining index might be associated with tumor progression and poor survival status in patients with gastrointestinal cancer. Meta-analysis.
miR (show MLXIP Proteins)-302c-3p play a pivotal role in the progression of glioma by targeting MTDH and is a potential inhibitor in glioma treatment.
Identify two novel factors, AKR1C2 (show AKR1C2 Proteins) (positive factor) and NF1 (show NF1 Proteins) (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer.
Knockdown of MTDH inhibits phosphorylation of AKT (show AKT1 Proteins) and increased apoptosis related protein expression.
EFEMP1 (show FBLN3 Proteins) might indirectly enhance the expression of MMP-2 (show MMP2 Proteins), providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB (show NFKB1 Proteins) pathways might be one of the effective ways which EFEMP1 (show FBLN3 Proteins) was induced by AEG-1.
AEG-1 mediates CCL3 (show CCL3 Proteins)/CCR5-induced EMT (show ITK Proteins) development via both Erk1/2 and Akt (show AKT1 Proteins) signaling pathway in CM patients, which indicates CCL3 (show CCL3 Proteins)/CCR5-AEG-1-EMT (show ITK Proteins) pathway could be suggested as a useful target to affect the progression of CM.
Data established that AEG-1 is frequently upregulated and functions as an oncogene (show RAB1A Proteins) by regulating several major signaling pathways in hepatocellular carcinoma (HCC (show FAM126A Proteins)) suggesting potential role as a biomarker or target for HCC (show FAM126A Proteins) therapy. [review]
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein