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Metalloproteinase Inhibitor 1 Proteins (TIMP1)

TIMP1 belongs to the TIMP gene family. Additionally we are shipping TIMP1 Antibodies (269) and TIMP1 Kits (130) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032
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Top TIMP1 Proteins at

Showing 10 out of 64 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Mouse Un-conjugated 10 μg Log in to see 10 to 12 Days
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
HOST_Human Cells Mouse Un-conjugated 10 μg Log in to see 16 Days
HOST_Human Cells Rat Un-conjugated 10 μg Log in to see 16 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_HEK-293 Cells Human His tag 10 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Log in to see 5 to 7 Days
HOST_Human Human Un-conjugated 10 μg Log in to see 5 to 6 Days

TIMP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine) , , , ,

Top referenced TIMP1 Proteins

  1. Human TIMP1 Protein expressed in HEK-293 - ABIN2666716 : Kim, Kim, Kang, Ko: Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression. in BMB reports 2012 (PubMed)
    Show all 4 references for ABIN2666716

  2. Mouse (Murine) TIMP1 Protein expressed in HEK-293 - ABIN2666718 : Brew, Nagase: The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. in Biochimica et biophysica acta 2010 (PubMed)
    Show all 4 references for ABIN2666718

  3. Rat (Rattus) TIMP1 Protein expressed in Human Cells - ABIN2009111 : Osthues, Knäuper, Oberhoff, Reinke, Tschesche: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. in FEBS letters 1992 (PubMed)
    Show all 4 references for ABIN2009111

  4. Human TIMP1 Protein expressed in Human Cells - ABIN2003615 : Aljada, Ramnath, Donohue, Harvey, Brooks, Wiseman, Khoury, Loewen, Slocum, Anderson, Bepler, Tan: Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 (PubMed)
    Show all 4 references for ABIN2003615

  5. Mouse (Murine) TIMP1 Protein expressed in Human Cells - ABIN2007691 : Hornebeck: Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. in Pathologie-biologie 2003 (PubMed)
    Show all 4 references for ABIN2007691

More Proteins for Metalloproteinase Inhibitor 1 (TIMP1) Interaction Partners

Cow (Bovine) Metalloproteinase Inhibitor 1 (TIMP1) interaction partners

  1. Decreased MMP-9 (show MMP9 Proteins) and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (show EGF Proteins) on MMP-9 (show MMP9 Proteins) and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha (show TNF Proteins), and hepatocyte growth factor (show HGF Proteins) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 (show TIMP2 Proteins) mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 (show TIMP2 Proteins) suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 (show TIMP2 Proteins) may play significant roles during luteal development and maintenance

  5. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Human Metalloproteinase Inhibitor 1 (TIMP1) interaction partners

  1. Serum TIMP1 did not differ significantly between normal weight, overweight, and obese participants.

  2. this study shows that increased TIMP-1 expression could promote the migration of hepatocellular carcinoma cells

  3. Tuberculosis patients have increased serum levels of TIMP-1 compared with healthy controls and pneumonia patients.

  4. The tumor/stroma TIMP-1 intensity ratio in tissue is useful to predict tumor recurrence in non-small cell lung cancer.

  5. Expression of TIMP-1 was significantly reduced in unstable carotid plaques compared with stable ones.

  6. TIMP-1 and-2 are primarily markers of an early function of the transplanted kidney.

  7. Increased expression ratio of MMP9 (show MMP9 Proteins)/TIMP-1 was observed in relapsing-remitting multiple sclerosis patients that responded to IFN-beta (show IFNB1 Proteins) therapy.

  8. High expression of TIMP-1 is associated with cardiovascular complications.

  9. MMP-9 (show MMP9 Proteins) activation rather than TIMP-1 may by associated with the pathomechanism of retinal ganglion cell and optic nerve damage in absolute glaucoma.

  10. Here we report isothermal titration calorimetric studies of the effects of selectivity-modifying mutations in NTIMP1 and NTIMP2 on the thermodynamics of their interactions with MMP1 (show MMP1 Proteins), MMP3 (show MMP3 Proteins), and MMP14 (show MMP14 Proteins).

Pig (Porcine) Metalloproteinase Inhibitor 1 (TIMP1) interaction partners

  1. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Proteins), TIMP1, and NGAL (show LCN2 Proteins) (also MMP2 (show MMP2 Proteins) in 220 kDa complex) without proteolytic activity.

  2. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1 (show FLT1 Proteins), VEGFR-2 (show KDR Proteins), and TIMP-1, which may contribute to the development of venous stenosis.

  3. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1 (show MMP1 Proteins), MMP-3 (show MMP3 Proteins), and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Mouse (Murine) Metalloproteinase Inhibitor 1 (TIMP1) interaction partners

  1. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  2. demonstrate that TIMP-2 (show TIMP2 Proteins) plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  3. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63 (show CD63 Proteins).

  4. TIMP-1 is a ligand of LRP-1 (show LRP1 Proteins) and we highlight a new example of its MMP-independent, cytokine-like functions.

  5. RAB37 (show RAB37 Proteins) regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 (show MMP9 Proteins) migration axis in vitro and in vivo and to suppress tumor metastasis.

  6. PDGF-D (show PDGFD Proteins) intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2 (show MMP2 Proteins)/MMP (show MMP2 Proteins)-9 (show MMP9 Proteins) system, and PDGF-D (show PDGFD Proteins) signaling is mediated through both PDGF (show PDGFA Proteins)-alpha and -beta receptors.

  7. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (show MAPK14 Proteins) signaling pathway.

  8. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 (show TIMP3 Proteins)-deficient mice.

  9. TNF-alpha (show TNF Proteins) produced by cholestasis can promote liver fibrosis via TIMP-1 production from hepatic stellate cells.

  10. These data suggest an MMP-independent role of TIMP-1 in regulating CD4 (show CD4 Proteins) T cell access into the CNS parenchyma during acute JHMV encephalitis

Rabbit Metalloproteinase Inhibitor 1 (TIMP1) interaction partners

  1. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (show MMP2 Proteins), MMP-9 (show MMP9 Proteins) and TIMP-1 in rabbits with acute paraquat poisoning.

TIMP1 Protein Profile

Protein Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Gene names and symbols associated with TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1)
  • TIMP metallopeptidase inhibitor 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (LOC100009047)
  • Clgi protein
  • EPA protein
  • EPO protein
  • HCI protein
  • Timp protein
  • TIMP-1 protein
  • TIMP1 protein

Protein level used designations for TIMP1

EG-1 , TIMP-1 , embryogenin-1 , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metalloproteinases 1 , tissue inhibitor of matrix metalloproteinase-1 , tissue inhibitor of metalloproteinase 1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase tissue inhibitor 1 , tissue inhibitor of metallopeptidase 1 , metalloproteinase tissue inhibitor , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

282092 Bos taurus
403816 Canis lupus familiaris
7076 Homo sapiens
396862 Sus scrofa
116510 Rattus norvegicus
443331 Ovis aries
21857 Mus musculus
100009047 Oryctolagus cuniculus
100034220 Equus caballus
574348 Macaca mulatta
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