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MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Additionally we are shipping MTA1 Proteins (7) and MTA1 Kits (1) and many more products for this protein.
Showing 10 out of 109 products:
Human Monoclonal MTA1 Primary Antibody for IF, WB - ABIN393781
Van Rechem, Boulay, Pinte, Stankovic-Valentin, Guérardel, Leprince: Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. in Molecular and cellular biology 2010
Show all 5 references for ABIN393781
Human Monoclonal MTA1 Primary Antibody for WB - ABIN393787
Li, Ohshiro, Khan, Kumar: Requirement of MTA1 in ATR-mediated DNA damage checkpoint function. in The Journal of biological chemistry 2010
Show all 5 references for ABIN393787
Human Polyclonal MTA1 Primary Antibody for WB - ABIN1881556
Zhu, Guo, Li, Ding, Chen: Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer. in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010
Show all 5 references for ABIN1881556
Chicken Polyclonal MTA1 Primary Antibody for WB - ABIN2780234
Kumar, Wang, Mazumdar, Talukder, Mandal, Yang, Bagheri-Yarmand, Sahin, Hortobagyi, Adam, Barnes, Vadlamudi: A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. in Nature 2002
Human Polyclonal MTA1 Primary Antibody for ELISA, WB - ABIN184623
Toh, Pencil, Nicolson: A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. in The Journal of biological chemistry 1994
MTA1 is up-regulated in CRC (show CALR Antibodies); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC Antibodies), VEGFD (show Figf Antibodies) and VEGFR3 (show FLT4 Antibodies)
We revealed a new molecular mechanism of MTA1-mediated invasion and metastasis in lung cancer through downstream target EpCAM (show EPCAM Antibodies), and interfering with EpCAM (show EPCAM Antibodies) function may be a novel therapeutic strategy for treatment of MTA1-overexpressing lung carcinoma
MTA1 plays an important role in Epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) to promote metastasis via suppressing E-cadherin (show CDH1 Antibodies) expression, resulting in a poor prognosis in MPM. MTA1 is a novel biomarker and indicative of a poor prognosis in MPM patients
Inhibition of MTA1 by ERalpha (show ESR1 Antibodies) contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis
protein abundance of YB-1 (show YBX1 Antibodies) and MTA1, irrespective of DNA or mRNA status, can predict for prostate cancer relapse and uncover a vast underappreciated repository of biomarkers regulated at the level of protein expression.
RNAi aiming at MTA1 can effectively inhibit the expression of MTA1 in endometrial carcinoma Ishikawa cells
report demonstrates that miR (show MLXIP Antibodies)-125a-3p inhibits the proliferation, migration, and invasion of NSCLC cells through down-regulation of MTA1
MTA1 drove a global decondensation of chromatin structure, it changed the expression of only a small proportion of genes.
MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.
MTA1 dysregulation in a subset of salivary gland cancer might promote aggressive phenotypes by compromising the tumor suppressor activity of ERbeta (show ESR2 Antibodies)
Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS (show TLR4 Antibodies)-induced acute lung injury, by selectively promoting the expression of NF-kappaB (show NFKB1 Antibodies)-regulated inflammatory cytokines.
MTA1 was regulated by HIF-1alpha (show HIF1A Antibodies) in hypoxia circumstance to suppress osteoblast differentiation.
MTA1 levels were increased in monosodium urate crystal-induced inflammation.
The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice.
Data suggest that nuclear metastasis-associated protein 1 (MTA1) is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers.
this study reports the potential signaling events related to up-regulation of metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells injury.
MTA1 has an important role in the maintenance of circadian rhythmicity.
the MTA1/NFkappaB/FasL (show FASL Antibodies) circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after Sertoli cell injury.
MTA1 is a major contributor to prostate tumor malignant progression.
Data indicate that metastasis tumor antigen 1 (MTA1)-dependent stimulation of STAT3 transcription through action on the MTA1/STAT3/Pol II coactivator complex.
Findings suggest that Mta3-NuRD complex, inclding component HDAC1 (show HDAC1 Antibodies), is essential for the initiation of primitive hematopoiesis.
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.
metastasis associated gene 1 protein
, metastasis-associated protein MTA1
, metastasis associated family, member 3
, metastasis-associated protein MTA3