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MTA2 encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. Additionally we are shipping MTA2 Kits (6) and MTA2 Proteins (4) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal MTA2 Primary Antibody for EIA, IF - ABIN500495
Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998
Show all 4 references for ABIN500495
Human Polyclonal MTA2 Primary Antibody for IHC (fro), WB - ABIN265128
Tanaka, Arakawa, Yamaguchi, Shiraishi, Fukuda, Matsui, Takei, Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. in Nature 2000
Show all 4 references for ABIN265128
Cow (Bovine) Polyclonal MTA2 Primary Antibody for IHC, WB - ABIN2781484
Schiene-Fischer, Yu: Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. in FEBS letters 2001
Show all 2 references for ABIN2781484
Human Polyclonal MTA2 Primary Antibody for EIA, WB - ABIN453277
Cui, Niu, Pestell, Kumar, Curran, Liu, Fuqua: Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. in Molecular endocrinology (Baltimore, Md.) 2006
Cow (Bovine) Polyclonal MTA2 Primary Antibody for WB - ABIN2779980
Blackshaw, Harpavat, Trimarchi, Cai, Huang, Kuo, Weber, Lee, Fraioli, Cho, Yung, Asch, Ohno-Machado, Wong, Cepko: Genomic analysis of mouse retinal development. in PLoS biology 2004
Cow (Bovine) Polyclonal MTA2 Primary Antibody for WB - ABIN2776428
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Cow (Bovine) Polyclonal MTA2 Primary Antibody for WB - ABIN2780615
Yao, Yang: The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. in The Journal of biological chemistry 2003
These results indicated there might be a tight correlation among MTA2, Ki-67 (show MKI67 Antibodies) and hepatocellular carcinoma prognosis
MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC (show CALR Antibodies).
MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 (show IL11 Antibodies) is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth
MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule (show MCAM Antibodies) Ep-CAM (show EPCAM Antibodies) and E-cadherin (show CDH1 Antibodies), suggesting that it might be a potential therapeutic target in NSCLC.
High MTA2 protein and mRNA expression is associated with glioma.
MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization.
MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer.
Study demonstrates that hBD-3 (show DEFB103A Antibodies) inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression.
Mta2 and Tipin (show TIPIN Antibodies) cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.
MTA2 knockdown impairs invasion and metastasis of gastric cancer cells.
Mta2 expression is up-regulated during testicular Sertoli cells phagocytosis.
Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR (show FSHR Antibodies) gene during spermatogenesis.
investigation of expression/role of Mta2 in zygote/blastocyst development: Mta2 appears to be only Mta (show DNMT1 Antibodies) expressed in zygotes; Mta2 appears to control transcription/expression of H19 (show NCKAP1 Antibodies) and Peg3 (show PEG3 Antibodies) in blastocysts; Mta2 may be involved in genetic imprinting
results suggest that GATA-3 (show GATA3 Antibodies) interacts with MTA-2 to co-ordinately regulate Th2 cytokine and ifng (show IFNG Antibodies) loci during T helper cell differentiation.
Assignment of the metastasis-associated gene (Mta1 (show MTA1 Antibodies)) to mouse chromosome band 12F and the metastasis-associated gene 2 (show MAG Antibodies) (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization
These results demonstrate the importance of FOG-2 (show ZFPM2 Antibodies)/MTA (show DNMT1 Antibodies)/RbAp interactions for FOG-2 (show ZFPM2 Antibodies)-mediated transcriptional repression and further define the molecular interactions between the FOG (show APAF1 Antibodies) repression motif and the NuRD complex.
Mta2/NuRD is involved in modulating IL-4 (show IL4 Antibodies) and IFN-gamma (show IFNG Antibodies) expression in T cell immune responses
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
metastasis associated 1 family, member 2
, metastasis-associated protein MTA2-like
, metastasis associated 1-like protein
, MTA1-L1 protein
, metastasis -associated gene 1-like 1
, metastasis associated gene family, member 2
, metastasis-associated 1-like 1
, metastasis-associated protein 2
, metastasis-associated protein MTA2
, p53 target protein in deacetylase complex
, metastasis-associated gene family, member 2
, metastais-associated gene family, member 2
, metastasis associated 1-like 1