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Metastasis Associated 1 Family, Member 2 Proteins (MTA2)

MTA2 encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. Additionally we are shipping MTA2 Antibodies (88) and MTA2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTA2 9219 O94776
Rat MTA2 MTA2 361724  
MTA2 23942 Q9R190
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Top MTA2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

MTA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Metastasis Associated 1 Family, Member 2 (MTA2) Interaction Partners

Human Metastasis Associated 1 Family, Member 2 (MTA2) interaction partners

  1. These results indicated there might be a tight correlation among MTA2, Ki-67 (show MKI67 Proteins) and hepatocellular carcinoma prognosis

  2. MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC (show CALR Proteins).

  3. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 (show IL11 Proteins) is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth

  4. MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule (show MCAM Proteins) Ep-CAM (show EPCAM Proteins) and E-cadherin (show CDH1 Proteins), suggesting that it might be a potential therapeutic target in NSCLC.

  5. High MTA2 protein and mRNA expression is associated with glioma.

  6. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization.

  7. MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer.

  8. Study demonstrates that hBD-3 (show DEFB103A Proteins) inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression.

  9. Mta2 and Tipin (show TIPIN Proteins) cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  10. MTA2 knockdown impairs invasion and metastasis of gastric cancer cells.

Mouse (Murine) Metastasis Associated 1 Family, Member 2 (MTA2) interaction partners

  1. Mta2 expression is up-regulated during testicular Sertoli cells phagocytosis.

  2. Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR (show FSHR Proteins) gene during spermatogenesis.

  3. investigation of expression/role of Mta2 in zygote/blastocyst development: Mta2 appears to be only Mta (show DNMT1 Proteins) expressed in zygotes; Mta2 appears to control transcription/expression of H19 (show NCKAP1 Proteins) and Peg3 in blastocysts; Mta2 may be involved in genetic imprinting

  4. results suggest that GATA-3 (show GATA3 Proteins) interacts with MTA-2 to co-ordinately regulate Th2 cytokine and ifng (show IFNG Proteins) loci during T helper cell differentiation.

  5. Assignment of the metastasis-associated gene (Mta1 (show MTA1 Proteins)) to mouse chromosome band 12F and the metastasis-associated gene 2 (show MAG Proteins) (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization

  6. These results demonstrate the importance of FOG-2/MTA (show DNMT1 Proteins)/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG (show APAF1 Proteins) repression motif and the NuRD complex.

  7. Mta2/NuRD is involved in modulating IL-4 (show IL4 Proteins) and IFN-gamma (show IFNG Proteins) expression in T cell immune responses

MTA2 Protein Profile

Protein Summary

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Gene names and symbols associated with MTA2

  • metastasis associated 1 family, member 2 (mta2)
  • metastasis associated 1 family, member 2 (MTA2)
  • metastasis associated 1 family, member 2 (Mta2)
  • metastasis-associated gene family, member 2 (Mta2)
  • preimplantation development (pid)
  • AW550797 protein
  • DKFZp470E0911 protein
  • fd61b05 protein
  • Mata1l1 protein
  • mmta2 protein
  • Mta1l1 protein
  • MTA2 protein
  • PID protein
  • wu:fd61b05 protein
  • wu:fi29g02 protein
  • zgc:63487 protein

Protein level used designations for MTA2

metastasis associated 1 family, member 2 , metastasis-associated protein MTA2-like , metastasis associated 1-like protein , MTA1-L1 protein , metastasis -associated gene 1-like 1 , metastasis associated gene family, member 2 , metastasis-associated 1-like 1 , metastasis-associated protein 2 , metastasis-associated protein MTA2 , p53 target protein in deacetylase complex , metastasis-associated gene family, member 2 , metastais-associated gene family, member 2 , metastasis associated 1-like 1

GENE ID SPECIES
100126057 Xenopus (Silurana) tropicalis
100174093 Pongo abelii
100393564 Callithrix jacchus
100467866 Ailuropoda melanoleuca
100604491 Nomascus leucogenys
399148 Xenopus laevis
9219 Homo sapiens
476057 Canis lupus familiaris
515389 Bos taurus
361724 Rattus norvegicus
326078 Danio rerio
23942 Mus musculus
18698 Mus musculus
451255 Pan troglodytes
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