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Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity). Additionally we are shipping MTA3 Antibodies (56) and MTA3 Proteins (5) and many more products for this protein.
Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers.
MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX (show BAX ELISA Kits), PARP (show COL11A2 ELISA Kits) expression.
This review focuses on the current knowledge about the function and regulation of MTA1 (show MTA1 ELISA Kits) and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival.
Using western blotting and luciferase assays, MTA3 was identified as a target of miR (show MLXIP ELISA Kits)-495
MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma.
Down-regulation of MTA3 and up-regulation of CGB5 (show CGB ELISA Kits) and Snail (show SNAI1 ELISA Kits) are associated with preeclampsia.
MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas
The absence of MTA3 leads to aberrant expression of Snail (show SNAI1 ELISA Kits), a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin (show CDH1 ELISA Kits), causing changes in epithelial architecture and invasive growth.
MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA (show DNMT1 ELISA Kits) proteins.
Bcl6 (show BCL6 ELISA Kits) middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Metastasis-associated protein 3 (show HSPB3 ELISA Kits) (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex.
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity).
metastasis associated 1 family, member 3
, metastasis associated 3
, metastasis-associated protein MTA3-like
, metastasis associated family, member 3
, metastasis associated gene family, member 3
, metastasis-associated protein MTA3