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May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.. Additionally we are shipping MTSS1 Antibodies (43) and many more products for this protein.
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Human MTSS1 Protein expressed in Escherichia coli (E. coli) - ABIN2005419
Glassmann, Molly, Surchev, Nazwar, Holst, Hartmann, Baader, Oberdick, Pietsch, Schilling: Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. in BMC developmental biology 2008
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Down-regulation of MTSS1 expression is associated with lymph node metastasis in Pancreatic Cancer.
Low expression of Mtss1 is associated with Chronic myeloid leukemia (show BCL11A Proteins).
MTSS1 plays an essential inhibitory role in the development and progression of ovarian cancers
human breast tumors data sets the MTSS1/p63 (show RPE65 Proteins) co-expression is a negative prognostic factor on patient survival, suggesting that the MTSS1/p63 (show RPE65 Proteins) axis might be functionally important to regulate breast tumor progression
our findings suggest that MTSS1 might have a context-dependent function and could act as a tumor suppressor, which is pharmacologically targetable in AML (show RUNX1 Proteins) patients.
EGF (show EGF Proteins) induces microRNAs that target suppressors of cell migration: miR (show MLXIP Proteins)-15b targets MTSS1 in breast cancer.
These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN (show CTTN Proteins) and as a prognosis biomarker in Glioblastomas
Data shows that MTSS1 is highly expressed in non-small-cell lung carcinomas compared with non-neoplastic lung tissues and may serve as an independent prognostic factor.
The absence of MIM led to PTPdelta-mediated activation of SRC (show SRC Proteins).
Study provides a novel molecular mechanism for the negative regulation of MTSS1 by beta-TRCP (show BTRC Proteins) in cancer cells.
Identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion via its I-BAR domain.
The data demonstrated for the first time an important role for missing-in-metastasis protein in B-cell development. There was a predisposition of missing-in-metastasis-null mice to develop diffuse large B lymphomas.
MTSS1 might be involved in shaping neuronal membranes in vivo.
endogenous MIM protein regulates globally the cell architecture and endocytosis that ultimately influence a variety of cellular behaviors, including cell polarity, motility, receptor signaling and membrane ruffling
MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Results suggest that MIM promotes ciliogenesis by antagonizing Src (show SRC Proteins)-dependent phosphorylation of Cortactin (show CTTN Proteins) and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh (show SHH Proteins) signaling during tissue regeneration.
tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain
Hedgehog (show SHH Proteins)-responsive gene MIM cooperates with receptor protein tyrosine phosphatase (show PTPRT Proteins)-delta (show PTPRD Proteins) to induce cytoskeletal remodeling.
Mtss1 represents a novel signaling pathway from PDGF (show PDGFA Proteins) receptor to the actin cytoskeleton via Src (show SRC Proteins)-related kinases.
The crystal structures of MIM's IMD and that of its WH2 bound to actin was determined.
morphogenetic pathway involving Daam1 (show DAAM1 Proteins) and MIM that transduces non-canonical Wnt (show WNT2 Proteins) signaling for the cytoskeletal changes and membrane dynamics required for vertebrate neural tube closure
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
metastasis suppressor 1
, metastasis suppressor protein 1
, metastasis suppressor protein 1-like
, metastasis suppressor YGL-1
, missing in metastasis protein
, actin monomer-binding protein