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May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.. Additionally we are shipping MTSS1 Proteins (4) and many more products for this protein.
Showing 10 out of 72 products:
Human Monoclonal MTSS1 Primary Antibody for IHC (p), ELISA - ABIN3013366
Parr, Jiang: Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. in European journal of cancer (Oxford, England : 1990) 2009
Show all 5 Pubmed References
Human Polyclonal MTSS1 Primary Antibody for IF (p), IHC (p) - ABIN762056
Chen, Chen, Zhao, Yang, Imran, Xing: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model. in Journal of cancer research and clinical oncology 2013
Data identify MTSS1 as a new Akt2 (show AKT2 Antibodies)-regulated gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 (show AKT2 Antibodies) in CRC (show CALR Antibodies) cells.
Data suggest that overexpression of MAEL (show MAEL Antibodies), caused by gene amplification and/or decreased miR (show MLXIP Antibodies)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1.
Overexpression of MTSS1 in PDAC cell lines leads to a loss of migratory potential in vitro and an increase in overall survival in vivo. Data provide insight into an important role for MTSS1 in suppressing tumor cell invasion and migration driven by the tumor microenvironment.
Overexpression of MTSS1 reduced BUCC cell proliferation, cell-cycle progression and colony formation, but had no influence on BUCC cell apoptosis.
in contrast to MIM, which is a prototype of I-BAR proteins and does not contain an SH3 domain (show ITSN1 Antibodies), IRTKS (show BAIAP2L1 Antibodies) promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 (show MAPK1/3 Antibodies) and p38 (show CRK Antibodies)
this study shows a previously unknown property of MIM that establishes the linkage of protein ubiquitylation with Rab (show HRB Antibodies)-guided trafficking of CXCR4 (show CXCR4 Antibodies) in endocytic vesicles
MTSS1 suppressed H1299 cell migration and invasion, and its expression level can be used as a new independent factor for determining the prognosis of non-small cell lung cancer.
MTSS1 is a new authentic target of miR (show MLXIP Antibodies)-96 in prostate carcinoma.
Down-regulation of MTSS1 expression is associated with lymph node metastasis in Pancreatic Cancer.
Low expression of Mtss1 is associated with Chronic myeloid leukemia (show BCL11A Antibodies).
Study showed that MTSS1 regulates neurite outgrowth and dendritic arborization in primary neurons in vitro, possibly through a Rac1- and PIP (show PIP Antibodies)-dependent pathway.
role of MIM in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4 (show CXCR4 Antibodies)/SDF-1 (show CXCL12 Antibodies) axis and interactions of BM leukocytes with their microenvironments.
Identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion via its I-BAR domain.
The data demonstrated for the first time an important role for missing-in-metastasis protein in B-cell development. There was a predisposition of missing-in-metastasis-null mice to develop diffuse large B lymphomas.
MTSS1 might be involved in shaping neuronal membranes in vivo.
endogenous MIM protein regulates globally the cell architecture and endocytosis that ultimately influence a variety of cellular behaviors, including cell polarity, motility, receptor signaling and membrane ruffling
MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Results suggest that MIM promotes ciliogenesis by antagonizing Src (show SRC Antibodies)-dependent phosphorylation of Cortactin (show CTTN Antibodies) and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh (show SHH Antibodies) signaling during tissue regeneration.
tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain
Hedgehog (show SHH Antibodies)-responsive gene MIM cooperates with receptor protein tyrosine phosphatase (show PTPRT Antibodies)-delta (show PTPRD Antibodies) to induce cytoskeletal remodeling.
morphogenetic pathway involving Daam1 (show DAAM1 Antibodies) and MIM that transduces non-canonical Wnt (show WNT2 Antibodies) signaling for the cytoskeletal changes and membrane dynamics required for vertebrate neural tube closure
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
metastasis suppressor 1
, metastasis suppressor protein 1
, metastasis suppressor protein 1-like
, metastasis suppressor YGL-1
, missing in metastasis protein
, actin monomer-binding protein