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Methionine Adenosyltransferase I, alpha Proteins (MAT1A)

MAT1A encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Additionally we are shipping Methionine Adenosyltransferase I, alpha Antibodies (52) and Methionine Adenosyltransferase I, alpha Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAT1A 17420 P51949
MAT1A 4143 Q00266
MAT1A 25331 P13444
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Top Methionine Adenosyltransferase I, alpha Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,098.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$534.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   1 mg Log in to see 6 Days
$102.00
Details

MAT1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced Methionine Adenosyltransferase I, alpha Proteins

  1. Human MAT1A Protein expressed in Escherichia coli (E. coli) - ABIN667767 : Ding, Mouzaki, You, Laird, Mato, Lu, Rountree: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. in Hepatology (Baltimore, Md.) 2009 (PubMed)
    Show all 2 references for ABIN667767

More Proteins for Methionine Adenosyltransferase I, alpha (MAT1A) Interaction Partners

Mouse (Murine) Methionine Adenosyltransferase I, alpha (MAT1A) interaction partners

  1. MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.

  2. Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.

  3. DUSP1 (show DUSP1 Proteins) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.

  4. investigated the function of the Cdk7 (show CDK7 Proteins).cyclin (show PCNA Proteins) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells

  5. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A

  6. MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (show HGF Proteins). MAT1A-produced SAMe has a major role in ERK (show EPHB2 Proteins) signaling & cyclin D1 (show CCND1 Proteins) regulation during liver regeneration & mitogenic signal response.

  7. Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.

  8. C/EBPbeta (show CEBPB Proteins) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A

  9. By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (show APEX1 Proteins) levels

  10. CD133(+)CD45(-) oval cells isolated from premalignant 16-month-old Mat1a(-/-) mice demonstrated significant resistance to transforming growth factor-beta-induced apoptosis compared to CD133(-) cells.

Human Methionine Adenosyltransferase I, alpha (MAT1A) interaction partners

  1. High PED expression is associated with esophageal carcinoma.

  2. The nuclear translocation of SApErk1/ 2 apart from PEA-15 (show PEA15 Proteins) as an important mechanism to reverse senescence phenotype.

  3. Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 (show PEA15 Proteins) pathway.

  4. New therapeutic targets based around PEA-15 (show PEA15 Proteins) and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  5. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  6. Omi/HtrA2 (show HTRA2 Proteins) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Proteins) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  7. Results suggest that neurochemical adaptations of brain FADD (show FADD Proteins), as well as its interaction with PEA-15 (show PEA15 Proteins), could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

  8. Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15 (show PEA15 Proteins)) influences dephosphorylation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm.

  9. 5-Aza-CdR (show RUNX1T1 Proteins) showed no effects on MAT2A (show MAT2A Proteins) methylation.

  10. Tumor suppressor PEA15 (show PEA15 Proteins) is a regulator of genome integrity and is an integral component of the DNA damage response pathway.

Methionine Adenosyltransferase I, alpha (MAT1A) Protein Profile

Protein Summary

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with MAT1A

  • menage a trois 1 (Mnat1)
  • methionine adenosyltransferase I, alpha (mat1a)
  • methionine adenosyltransferase I, alpha (MAT1A)
  • methionine adenosyltransferase I, alpha (Mat1a)
  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • AdoMet protein
  • AI046368 protein
  • Ams protein
  • E130115E11Rik protein
  • HMAT1 protein
  • HUMMAT1H protein
  • MAT protein
  • MAT1 protein
  • MAT1H protein
  • MATA1 protein
  • P36 protein
  • PEA-15 protein
  • PED protein
  • SADE protein
  • SAMS protein
  • SAMS1 protein
  • SAS protein
  • wu:fi35e01 protein
  • zgc:55442 protein

Protein level used designations for MAT1A

CDK-activating kinase assembly factor MAT1 , CDK7/cyclin H assembly factor , CDK7/cyclin-H assembly factor , RING finger protein MAT1 , p35 , S-adenosylmethionine synthase isoform type-1 , MAT 1 , MAT-I/III , S-adenosylmethionine synthetase isoform type-1 , adoMet synthase 1 , adoMet synthetase 1 , methionine adenosyltransferase 1 , methionine adenosyltransferase I/III , S - adenosylmethionine synthetase , 15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes

GENE ID SPECIES
17420 Mus musculus
334195 Danio rerio
423628 Gallus gallus
4143 Homo sapiens
608788 Canis lupus familiaris
100156922 Sus scrofa
541078 Bos taurus
11720 Mus musculus
25331 Rattus norvegicus
8682 Homo sapiens
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