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Methionyl Aminopeptidase 2 Proteins (METAP2)

METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. Additionally we are shipping Methionyl Aminopeptidase 2 Antibodies (77) and Methionyl Aminopeptidase 2 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
METAP2 56307 O08663
METAP2 10988 P50579
METAP2 64370 P38062
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Top Methionyl Aminopeptidase 2 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Encephalitozoon cuniculi His tag   1 mg Log in to see 56 to 66 Days
$2,977.33
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,173.50
Details
Yeast Candida albicans His tag   1 mg Log in to see 56 to 66 Days
$3,254.17
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,256.00
Details
Yeast Candida His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,344.00
Details

METAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

Top referenced Methionyl Aminopeptidase 2 Proteins

  1. Mouse (Murine) METAP2 Protein expressed in Baculovirus infected Insect Cells - ABIN2007931 : Johansson, Bond, Nielsen, Moubaraki, Murray, Berry, Larrabee, McKenzie: Dicobalt II-II, II-III, and III-III complexes as spectroscopic models for dicobalt enzyme active sites. in Inorganic chemistry 2008 (PubMed)
    Show all 2 references for ABIN2007931

More Proteins for Methionyl Aminopeptidase 2 (METAP2) Interaction Partners

Mouse (Murine) Methionyl Aminopeptidase 2 (METAP2) interaction partners

  1. the functional role of S100A4 (show S100A4 Proteins) in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2.

  2. The stability of p67 increases during myotube formation while inhibiting the phosphorylation of ERKs 1 and 2.

  3. demonstrate an essential role for MetAP-2 in angiogenesis and indicate that MetAP-2 is responsible for the endothelial cell growth arrest induced by fumagillin and its derivatives

  4. Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis.

  5. MetAP2 plays an important role in tumor cell growth and may contribute to tumorigenesis

  6. Discovery, identification, and characterization of candidate pharmacodynamic markers of Metap2 inhibition are reported.

Human Methionyl Aminopeptidase 2 (METAP2) interaction partners

  1. Suggest MetAP2 as important regulator of proliferation/apoptosis in non-small cell lung cancers.

  2. Nt-acetylation prevents the excision of the initiator methionine by MetAP2.

  3. Data indicate that methionine aminopeptidase 2 (MetAP2) contains a single disulfide bond that exists in oxidized and reduced states and influences enzyme function.

  4. The activity of unmodified, nitrated and oxidised METAP2 was assessed and it was found that nitration significantly reduced its ability to cleave a chromogenic substrate. Mass spectrometry analysis identified Tyr336 as a nitrated residue in METAP2.

  5. Increased expression of METAP2 is associated with pilocytic astrocytoma.

  6. This study demonstrated a hitherto-undescribed role of MetAP2 in definitive hematopoiesis and a possible link to noncanonical Wnt (show WNT2 Proteins) and ERK (show EPHB2 Proteins) signaling.

  7. the substrate specificities of Escherichia coli MetAP1 (show METAP1 Proteins), human MetAP1 (show METAP1 Proteins), and human MetAP2 were systematically profiled

  8. Data indicate that MetAP2 expression and pp60c-src (show SRC Proteins) phosphorylation were decreased in NC2213 treated cells.

  9. the functional role of S100A4 (show S100A4 Proteins) in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2.

  10. MetAP-1 (show METAP1 Proteins) and MetAP-2 have essential functions in the control of mammalian cell proliferation

Zebrafish Methionyl Aminopeptidase 2 (METAP2) interaction partners

  1. This study demonstrated a hitherto-undescribed role of MetAP2 in definitive hematopoiesis and a possible link to noncanonical Wnt (show WNT2 Proteins) and ERK (show MAPK1 Proteins) signaling.

Methionyl Aminopeptidase 2 (METAP2) Protein Profile

Protein Summary

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.

Gene names and symbols associated with METAP2

  • methionine aminopeptidase 2 (metap2)
  • methionyl aminopeptidase 2 (METAP2)
  • methionyl aminopeptidase 2 (metap2)
  • methionine aminopeptidase 2 (Metap2)
  • methionyl aminopeptidase 2 (LOC100230046)
  • methionine aminopeptidase (MAP2)
  • methionyl aminopeptidase 2 (Metap2)
  • methionyl aminopeptidase 2b (metap2b)
  • 4930584B20Rik protein
  • A930035J23Rik protein
  • AI047573 protein
  • AL024412 protein
  • Amp2 protein
  • AU014659 protein
  • DDBDRAFT_0190923 protein
  • DDBDRAFT_0304991 protein
  • DDB_0190923 protein
  • DDB_0304991 protein
  • GB13458 protein
  • MAP2 protein
  • METAP2 protein
  • MGC53792 protein
  • MNPEP protein
  • p67 protein
  • p67eIF2 protein
  • wu:fb98h06 protein
  • zgc:66250 protein

Protein level used designations for METAP2

methionine aminopeptidase 2 , methionyl aminopeptidase 2 , methionine aminopeptidase 2-like , hypothetical protein , MAP 2 , eIF-2-associated p67 , initiation factor 2-associated 67 kDa glycoprotein , initiation factor 2-associated protein (p67) , metAP 2 , peptidase M 2 , eIF-2-associated p67 homolog , initiation factor 2 associated 67 kDa protein , p67eIF2

GENE ID SPECIES
380164 Xenopus laevis
452141 Pan troglodytes
548869 Xenopus (Silurana) tropicalis
551771 Apis mellifera
712400 Macaca mulatta
8617632 Dictyostelium discoideum AX4
100052132 Equus caballus
100409642 Callithrix jacchus
100448711 Pongo abelii
100470433 Ailuropoda melanoleuca
100593728 Nomascus leucogenys
417912 Gallus gallus
100230046 Taeniopygia guttata
3647837 Candida albicans SC5314
56307 Mus musculus
443662 Xenopus laevis
10988 Homo sapiens
475429 Canis lupus familiaris
404150 Bos taurus
64370 Rattus norvegicus
323452 Danio rerio
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