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anti-Methyl CpG Binding Protein 2 (MECP2) Antibodies

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Additionally we are shipping Methyl CpG Binding Protein 2 Proteins (12) and Methyl CpG Binding Protein 2 Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MECP2 29386 Q00566
MECP2 17257 Q9Z2D6
MECP2 4204 P51608
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Top anti-Methyl CpG Binding Protein 2 Antibodies at antibodies-online.com

Showing 10 out of 218 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of MeCP2 (arrow) using rabbit polyclonal MeCP2 Antibody (E11) (ABIN650708). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MeCP2 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of MeCP2 (arrow) using rabbit polyclonal MeCP2 Antibody (C413) (ABIN650709). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MeCP2 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MECP2 Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of MeCP2-S421 (ABIN389123) in mouse brain, cerebellum tissue and HepG2 cell line lysates (35 µg/lane). CP2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of MDA-MB435 cells using MeCP2 Antibody (N-term) Cat.-No AP52648PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin fixed, paraffin embedded human brain tissue stained with MeCP2 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MECP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MECP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB MeCP2 Antibody (pS80)  western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the MeCP2 antibody detected the MeCP2 protein (arrow). MeCP2 Antibody (N-term S80) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MeCP2 Antibody (N-term S80) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details

MECP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
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Mouse (Murine)
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Top referenced anti-Methyl CpG Binding Protein 2 Antibodies

  1. Human Polyclonal MECP2 Primary Antibody for EIA, WB - ABIN357797 : dos Santos, Abdalla, Campos, Santos-Rebouças, Pimentel: The A140V mutation in the MECP2 gene is not a common etiological factor among Brazilian mentally retarded males. in Neuroscience letters 2005 (PubMed)
    Show all 4 references for ABIN357797

  2. Human Polyclonal MECP2 Primary Antibody for EIA, FACS - ABIN953366 : Shapiro, Bibat, Hiremath, Blue, Hundalani, Yablonski, Kantipuly, Rohde, Johnston, Naidu: Bone mass in Rett syndrome: association with clinical parameters and MECP2 mutations. in Pediatric research 2010 (PubMed)
    Show all 3 references for ABIN953366

  3. Dog (Canine) Polyclonal MECP2 Primary Antibody for WB - ABIN2781332 : Robertson, Hall, Jacoby, Ellaway, de Klerk, Leonard: The association between behavior and genotype in Rett syndrome using the Australian Rett Syndrome Database. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006 (PubMed)
    Show all 2 references for ABIN2781332

  4. Human Polyclonal MECP2 Primary Antibody for FACS, WB - ABIN650708 : Fang, Cheng, Chen, Lu, Yang, Zhu, Lu: Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. in World journal of gastroenterology : WJG 2004 (PubMed)

  5. Human Polyclonal MECP2 Primary Antibody for EIA - ABIN358521 : Tao, Hu, Chang, Wu, Sherman, Martinowich, Klose, Schanen, Jaenisch, Wang, Sun: Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)

More Antibodies against Methyl CpG Binding Protein 2 Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Study showed that Mecp2 de fi ciency causes a reduced amplitude in the PER2 (show PER2 Antibodies) expression rhythms of the suprachiasmatic nucleus providing a new insight into behavioral dysfunction caused by Mecp2 de fi ciency in Rett syndrome.

  2. Cigarette smoke induces proteosomal-mediated degradation of MeCP-2 in embryonic orofacial cells.

  3. Study shows that embryonic primary cortical neurons of Mecp2 null mice display reduced neurite complexity possibly reflecting transcriptional changes that occur long before onset of Rett symptoms.

  4. MeCP2 binding downstream of promoters correlates with increased expression in Mecp2-deficient neurons. Genome-wide association with methylation is in part due to MeCP2's affinity to GC-rich (show RELB Antibodies) chromatin.

  5. MeCP2 induced aggregation of heterochromatin that was enhanced in PARP1 (show PARP1 Antibodies)-/- cells.

  6. Findings establish miR (show MLXIP Antibodies)-199a as a critical downstream target of MeCP2 in RTT pathogenesis by linking MeCP2 with mTOR (show FRAP1 Antibodies) signaling.

  7. Results together reveal an important role of MeCP2 SUMOylation in social interaction, memory and synaptic plasticity, and that abnormal MeCP2 SUMOylation is implicated in Rett syndrome.

  8. These results provide new insight into both the fundamental neurobiology of RTT, and potential therapeutic strategies via NF-kappaB (show NFKB1 Antibodies) pathway modulation.

  9. Loss of MeCP2 in astrocytes alone is sufficient to result in a dramatic attenuation of the HCVR.

  10. Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Xq28 duplication involving MECP2 is associated with brain diseases.

  2. A statistically significant difference was observed in the rs2239464 and rs2075596 polymorphisms of MECP2 between Systemic lupus erythematosus subjects and controls.

  3. We generated induced pluripotent stem cells (iPSCs) from patients with the MECP2 duplication syndrome (MECP2dup), carrying different duplication sizes, to study the impact of increased MeCP2 dosage in human neurons

  4. Study shows that MECP2 is commonly amplified oncogene (show RAB1A Antibodies) in human malignancies with a unique epigenetic mechanism of action where its binding to 5-hydroxymethylcytosine is important for its anchorage-independent growth.

  5. The aim of the present study was to evaluate the potential of MeCP2 for use as a therapeutic target for human colorectal cancer.

  6. Functional performance in Rett syndrome patients may relate to the type of Mecp2 mutation

  7. The MECP-2 is the direct targets of miR (show MLXIP Antibodies)-370 and miR (show MLXIP Antibodies)-373, respectively, in human articular chondrocytes.

  8. revealed a genotype-specific effect of methyl-CpG-binding protein-2 (MeCP2) dysfunction on iPSC-derived neuronal migration and maturation (reduced neurite outgrowth and fewer synapses) in 3D layered hydrogels

  9. Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands.

  10. Study suggests that polymorphism in the MECP2 locus is associated with the susceptibility of Iranian patients to systemic lupus erythematosus.

Methyl CpG Binding Protein 2 (MECP2) Antigen Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Gene names and symbols associated with MECP2

  • methyl CpG binding protein 2 (Mecp2) antibody
  • methyl CpG binding protein 2 (Rett syndrome) (MECP2) antibody
  • 1500041B07Rik antibody
  • AUTSX3 antibody
  • BB130002 antibody
  • D630021H01Rik antibody
  • Mbd5 antibody
  • MRX16 antibody
  • MRX79 antibody
  • MRXS13 antibody
  • MRXSL antibody
  • PPMX antibody
  • RS antibody
  • RTS antibody
  • RTT antibody
  • WBP10 antibody

Protein level used designations for MECP2

meCP-2 protein , methyl-CpG-binding protein 2 , meCp-2 protein

GENE ID SPECIES
29386 Rattus norvegicus
17257 Mus musculus
4204 Homo sapiens
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