You are viewing an incomplete version of our website. Please click to reload the website as full version.

Methyl CpG Binding Protein 2 Proteins (MECP2)

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Additionally we are shipping Methyl CpG Binding Protein 2 Antibodies (216) and Methyl CpG Binding Protein 2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MECP2 29386 Q00566
MECP2 17257 Q9Z2D6
MECP2 4204 P51608
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Methyl CpG Binding Protein 2 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$522.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,375.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_HEK-293 Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$142.86
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

MECP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Mouse (Murine)

Human , , ,
,

More Proteins for Methyl CpG Binding Protein 2 (MECP2) Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Study showed that Mecp2 de fi ciency causes a reduced amplitude in the PER2 (show PER2 Proteins) expression rhythms of the suprachiasmatic nucleus providing a new insight into behavioral dysfunction caused by Mecp2 de fi ciency in Rett syndrome.

  2. Cigarette smoke induces proteosomal-mediated degradation of MeCP-2 in embryonic orofacial cells.

  3. Study shows that embryonic primary cortical neurons of Mecp2 null mice display reduced neurite complexity possibly reflecting transcriptional changes that occur long before onset of Rett symptoms.

  4. MeCP2 binding downstream of promoters correlates with increased expression in Mecp2-deficient neurons. Genome-wide association with methylation is in part due to MeCP2's affinity to GC-rich (show RELB Proteins) chromatin.

  5. MeCP2 induced aggregation of heterochromatin that was enhanced in PARP1 (show PARP1 Proteins)-/- cells.

  6. Findings establish miR (show MLXIP Proteins)-199a as a critical downstream target of MeCP2 in RTT pathogenesis by linking MeCP2 with mTOR (show FRAP1 Proteins) signaling.

  7. Results together reveal an important role of MeCP2 SUMOylation in social interaction, memory and synaptic plasticity, and that abnormal MeCP2 SUMOylation is implicated in Rett syndrome.

  8. These results provide new insight into both the fundamental neurobiology of RTT, and potential therapeutic strategies via NF-kappaB (show NFKB1 Proteins) pathway modulation.

  9. Loss of MeCP2 in astrocytes alone is sufficient to result in a dramatic attenuation of the HCVR.

  10. Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Xq28 duplication involving MECP2 is associated with brain diseases.

  2. A statistically significant difference was observed in the rs2239464 and rs2075596 polymorphisms of MECP2 between Systemic lupus erythematosus subjects and controls.

  3. We generated induced pluripotent stem cells (iPSCs) from patients with the MECP2 duplication syndrome (MECP2dup), carrying different duplication sizes, to study the impact of increased MeCP2 dosage in human neurons

  4. Study shows that MECP2 is commonly amplified oncogene (show RAB1A Proteins) in human malignancies with a unique epigenetic mechanism of action where its binding to 5-hydroxymethylcytosine is important for its anchorage-independent growth.

  5. The aim of the present study was to evaluate the potential of MeCP2 for use as a therapeutic target for human colorectal cancer.

  6. Functional performance in Rett syndrome patients may relate to the type of Mecp2 mutation

  7. The MECP-2 is the direct targets of miR (show MLXIP Proteins)-370 and miR (show MLXIP Proteins)-373, respectively, in human articular chondrocytes.

  8. revealed a genotype-specific effect of methyl-CpG-binding protein-2 (MeCP2) dysfunction on iPSC-derived neuronal migration and maturation (reduced neurite outgrowth and fewer synapses) in 3D layered hydrogels

  9. Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands.

  10. Study suggests that polymorphism in the MECP2 locus is associated with the susceptibility of Iranian patients to systemic lupus erythematosus.

Methyl CpG Binding Protein 2 (MECP2) Protein Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Gene names and symbols associated with MECP2

  • methyl CpG binding protein 2 (Mecp2)
  • methyl CpG binding protein 2 (Rett syndrome) (MECP2)
  • 1500041B07Rik protein
  • AUTSX3 protein
  • BB130002 protein
  • D630021H01Rik protein
  • Mbd5 protein
  • MRX16 protein
  • MRX79 protein
  • MRXS13 protein
  • MRXSL protein
  • PPMX protein
  • RS protein
  • RTS protein
  • RTT protein
  • WBP10 protein

Protein level used designations for MECP2

meCP-2 protein , methyl-CpG-binding protein 2 , meCp-2 protein

GENE ID SPECIES
29386 Rattus norvegicus
17257 Mus musculus
4204 Homo sapiens
Selected quality suppliers for Methyl CpG Binding Protein 2 Proteins (MECP2)
Did you look for something else?