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The protein encoded by MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). Additionally we are shipping MBD1 Antibodies (73) and MBD1 Kits (2) and many more products for this protein.
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Human MBD1 Protein expressed in Wheat germ - ABIN1310462
Jin, Kadam, Pfeifer: Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. in Nucleic acids research 2010
Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 (show DPEP1 Proteins) protein.
MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 Proteins)) gene polymorphisms and schizophrenia.
We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 (show DPEP1 Proteins) protein complex in maintaining central tolerance
an important function of MBD1 (show DPEP1 Proteins) in DNA repair and mediation of chemoradioresistance of cancer cells
higher MBD1 (show DPEP1 Proteins) expression correlated with lymph node metastasis and poor survival in pancreatic cancer; gain- and loss-of-function studies in vitro validated MBD1 (show DPEP1 Proteins) as a potent oncogene (show RAB1A Proteins) promoting pancreatic cancer cell invasion and epithelial-mesenchymal transition
MBD1-containing chromatin associated factor 2 (show ATF7IP2 Proteins), epithelial malignancy-related vimentin (show VIM Proteins) and exocytosis-related annexin A2 (show ANXA2 Proteins) were changed upon exposure to airborne nanoparticle PM(0.056).
This review tries to match MeCP2 (show MECP2 Proteins) structural domains, or their lack, and specific chromatin features needed for proper recruitment of MeCP2 (show MECP2 Proteins) to its functions as either activator or repressor. We specifically focused on MeCP2 (show MECP2 Proteins)'s role in Rett syndrome
lack of binding to mCpG and interaction with NuRD/Mi2 components HDAC1 (show HDAC1 Proteins) and MTA2 (show MTA2 Proteins)
Results show that methyl-CpG binding domain protein 1 (MBD1) is expressed in tumor cells, but methyl-CpG binding domain protein 2 (MBD2) and methyl CpG binding protein 2 (MeCP2 (show MECP2 Proteins)) are not.
H19 (show NCKAP1 Proteins) lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1 (show DPEP1 Proteins).
regulatory loop formed by MBD1 (show DPEP1 Proteins) and miR (show MLXIP Proteins)-195 is an important component of the epigenetic network that controls aNSC fate
MBD1 (show DPEP1 Proteins), miR (show MLXIP Proteins)-184, and Numbl (show NUMBL Proteins) form a regulatory network that helps control the balance between proliferation and differentiation of adult neural stem/progenitor cells.
Results indicate that MBD1 (show DPEP1 Proteins) can interpret the CpG dinucleotide as a repressive signal in vivo regardless of its methylation status.
These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE (show MAGEB10 Proteins)-A genes.
Mbd1 (show DPEP1 Proteins)(-/-) mice exhibit several core deficits associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity.
Mbd1 (show DPEP1 Proteins) and DNA methylation (show HELLS Proteins)-mediated epigenetic mechanism regulated the expression of stem cell mitogen Fgf-2 (show FGF2 Proteins) in adult neural stem/progenitor cells.
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions\; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides\; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
CXXC-type zinc finger protein 3
, methyl-CpG binding domain protein 1 isoform PCM1
, methyl-CpG-binding domain protein 1
, protein containing methyl-CpG-binding domain 1
, the regulator of fibroblast growth factor 2 (FGF-2) transcription
, methyl-CpG-binding protein MBD1