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Does not bind DNA by itself. Additionally we are shipping MBD3 Proteins (6) and MBD3 Kits (1) and many more products for this protein.
Showing 10 out of 107 products:
Human Monoclonal MBD3 Primary Antibody for WB - ABIN1882264
Tatematsu, Yamazaki, Ishikawa: MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. in Genes to cells : devoted to molecular & cellular mechanisms 2000
Show all 4 references for ABIN1882264
Human Polyclonal MBD3 Primary Antibody for EIA, IHC (p) - ABIN356576
Hendrich, Bird: Identification and characterization of a family of mammalian methyl-CpG binding proteins. in Molecular and cellular biology 1998
Show all 4 references for ABIN356576
Human Monoclonal MBD3 Primary Antibody for ICC, IHC (p) - ABIN252494
Balmer, Arredondo, Samaco, LaSalle: MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. in Human genetics 2002
Show all 3 references for ABIN252494
Chicken Polyclonal MBD3 Primary Antibody for WB - ABIN2778641
Brown, Szyf: Epigenetic programming of the rRNA promoter by MBD3. in Molecular and cellular biology 2007
Human Polyclonal MBD3 Primary Antibody for IHC (p), WB - ABIN387891
Bhattacharya, Ramchandani, Cervoni, Szyf: A mammalian protein with specific demethylase activity for mCpG DNA. in Nature 1999
Human Polyclonal MBD3 Primary Antibody for ELISA, WB - ABIN1533573
Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004
Human Polyclonal MBD3 Primary Antibody for WB - ABIN657677
Bachmann, Spengler, Binder, Eggermann: MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome. in European journal of medical genetics 2010
Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes.
This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 Antibodies)) gene polymorphisms and schizophrenia.
These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms
reduced mRNA expression of MBD2 (show DPEP2 Antibodies) and MBD3 is implicated in gastric carcinogenesis.
MBD3 is enriched at active promoters, whereas MBD2 (show DPEP2 Antibodies) is bound at methylated promoters and enriched at exon sequences of active genes.
These factors lead to a binding affinity hierarchy of p66alpha (show GATAD2A Antibodies) for the different MBD2 (show DPEP2 Antibodies) homologues (MBD2 (show DPEP2 Antibodies) approximately MBD3 > MBD3L1 (show MBD3L1 Antibodies) approximately MBD3L2 (show MBD3L2 Antibodies)).
MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome.
MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma
interaction with two highly related p66 (show POLD3 Antibodies) proteins
localization in Aurora-A (show AURKA Antibodies)-positive centrosomes in M phase
Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 (show DEFB103A Antibodies) in embryonic orofacial cells.
Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.
overexpression facilitates NANOG-mediated reprogramming in neural stem cells
Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Antibodies) and POLB (show POLB Antibodies) as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 Antibodies)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt (show WNT2 Antibodies) signaling genes
Study finds that Mbd3 and Brg1 (show SMARCA4 Antibodies) antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 (show SMARCA4 Antibodies) play key roles in the biology of 5-hydroxymethylcytosine.
the transactivation domain of c-Jun (show JUN Antibodies) recruits Mbd3/NuRD to AP-1 (show JUN Antibodies) target genes to mediate gene repression, and this repression is relieved by JNK (show MAPK8 Antibodies)-mediated c-Jun (show JUN Antibodies) N-terminal phosphorylation
Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells
MBD3 protein is differentially expressed in principal neurons of the hippocampus and cortex, and in the adult retina.
MBD3L2 (show MBD3L2 Antibodies) interacts with MBD3 and components of the NuRD complex and can oppose MBD2 (show MBD2 Antibodies)-MeCP1-mediated methylation silencing
Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.
methyl-CpG binding domain protein 3
, methyl-CpG binding protein MBD3 long form
, methyl-CpG-binding domain protein 3
, methyl-CpG-binding protein MBD3