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Methyl-CpG Binding Domain Protein 3 Proteins (MBD3)

Does not bind DNA by itself. Additionally we are shipping MBD3 Antibodies (105) and MBD3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MBD3 53615 O95983
MBD3 17192 Q9Z2D8
Rat MBD3 MBD3 362834  
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Top MBD3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

MBD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced MBD3 Proteins

  1. Human MBD3 Protein expressed in Escherichia coli (E. coli) - ABIN1098411 : Nan, Ng, Johnson, Laherty, Turner, Eisenman, Bird: Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. in Nature 1998 (PubMed)
    Show all 2 references for ABIN1098411

More Proteins for Methyl-CpG Binding Domain Protein 3 (MBD3) Interaction Partners

Human Methyl-CpG Binding Domain Protein 3 (MBD3) interaction partners

  1. Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes.

  2. This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 Proteins)) gene polymorphisms and schizophrenia.

  3. These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms

  4. reduced mRNA expression of MBD2 (show DPEP2 Proteins) and MBD3 is implicated in gastric carcinogenesis.

  5. MBD3 is enriched at active promoters, whereas MBD2 is bound at methylated promoters and enriched at exon sequences of active genes.

  6. These factors lead to a binding affinity hierarchy of p66alpha (show GATAD2A Proteins) for the different MBD2 (show DPEP2 Proteins) homologues (MBD2 (show DPEP2 Proteins) approximately MBD3 > MBD3L1 (show MBD3L1 Proteins) approximately MBD3L2 (show MBD3L2 Proteins)).

  7. MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome.

  8. MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma

  9. interaction with two highly related p66 (show POLD3 Proteins) proteins

  10. localization in Aurora-A (show AURKA Proteins)-positive centrosomes in M phase

Mouse (Murine) Methyl-CpG Binding Domain Protein 3 (MBD3) interaction partners

  1. Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 (show DEFB103A Proteins) in embryonic orofacial cells.

  2. Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.

  3. overexpression facilitates NANOG-mediated reprogramming in neural stem cells

  4. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Proteins) and POLB (show POLB Proteins) as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos.

  5. cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 Proteins)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt (show WNT2 Proteins) signaling genes

  6. Study finds that Mbd3 and Brg1 (show SMARCA4 Proteins) antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 (show SMARCA4 Proteins) play key roles in the biology of 5-hydroxymethylcytosine.

  7. the transactivation domain of c-Jun (show JUN Proteins) recruits Mbd3/NuRD to AP-1 (show JUN Proteins) target genes to mediate gene repression, and this repression is relieved by JNK (show MAPK8 Proteins)-mediated c-Jun (show JUN Proteins) N-terminal phosphorylation

  8. Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells

  9. MBD3 protein is differentially expressed in principal neurons of the hippocampus and cortex, and in the adult retina.

  10. MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing

MBD3 Protein Profile

Protein Summary

Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.

Gene names and symbols associated with MBD3

  • methyl-CpG binding domain protein 3 (mbd3)
  • methyl-CpG binding domain protein 3 (MBD3)
  • methyl-CpG binding domain protein 3 (Mbd3)
  • AI181826 protein
  • AU019209 protein
  • DKFZp459N1635 protein
  • MBD3 protein
  • MGC69548 protein
  • xmbd3 protein

Protein level used designations for MBD3

methyl-CpG binding domain protein 3 , methyl-CpG binding protein MBD3 long form , methyl-CpG-binding domain protein 3 , methyl-CpG-binding protein MBD3

GENE ID SPECIES
398135 Xenopus laevis
448748 Xenopus (Silurana) tropicalis
455554 Pan troglodytes
100172033 Pongo abelii
53615 Homo sapiens
17192 Mus musculus
362834 Rattus norvegicus
770153 Gallus gallus
485080 Canis lupus familiaris
616090 Bos taurus
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