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Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase Proteins (MTHFD1)

MTHFD1 encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Additionally we are shipping MTHFD1 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTHFD1 4522 P11586
Rat MTHFD1 MTHFD1 64300 P27653
MTHFD1 108156 Q922D8
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Top MTHFD1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
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MTHFD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) Interaction Partners

Human Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

  1. polymorphism of SNP loci rs1956545 and rs56811449 as well as a haplotype in MTHFD1 gene could have a role in the occurrence of neural tube defects in the Chinese population

  2. MTHFD1 1958G > A is significantly associated with the susceptibility of neural tube defects in a Chinese population.

  3. Data suggest impaired folate metabolism down-regulates placenta trophoblast proliferation, viability, invasive capacity, and progesterone secretion; silencing MTHFD1 gene down-regulates cell proliferation but does not alter progesterone secretion.

  4. We found that the compound mutation genotypes MTHFD-G1958A, MTR (show MTR Proteins)-A2756G, and RFC1 (show RFC1 Proteins)-G80A increased the risk of preterm birth (OR = 2.88, 95%CI = 1.08-7.72, P = 0.028).

  5. the present meta-analysis provided evidence of the association between maternal MTHFD1 G1958A polymorphism and neural tube defects susceptibility.

  6. We find no evidence for association of the MTHFD1 R134K and R653Q polymorphisms with migraine in our Australian case-control population

  7. The MTRR (show MTRR Proteins) c.66A>G (rs1801394) polymorphism and MTHFD1 c.1958G>A (rs2236225) are associated with increased maternal risk for Down syndrome. [Meta-analysis]

  8. The results indicated the MTHFD1 1958G>A polymorphism to be one of the important genetic determinants of NSCLP risk in South Indian subjects

  9. ACAT1 (show ACAT1 Proteins), ACACA, ALDH6A1 (show ALDH6A1 Proteins) and MTHFD1 represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.

  10. impact of MTHFD1 loss of function on folate-dependent purine, dTMP, and methionine biosynthesis in fibroblasts with MTHFD1 deficiency

Zebrafish Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

  1. Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (show ALDH1L1 Proteins)) involving CEBPalpha helps relieve embryonic oxidative stress induced (show SQSTM1 Proteins) by ethanol exposure.

Mouse (Murine) Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

  1. Deficiency of the MTHFD1 10-formyltetrahydrofolate synthetase activity in embryos is associated with increased incidence of congenital heart defects

  2. methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), an enzyme that generates methylenetetrahydrofolate from formate, ATP, and NADPH (show FDXR Proteins), functions in the nucleus to support de novo thymidylate biosynthesis.

  3. Mthfd1gt/+ mice exhibited attentional dysfunction and a blunted affective response to committing an error. They also showed decreased expression levels for genes encoding choline dehydrogenase and the alpha 7 nicotinic cholinergic receptor.

  4. Data suggest that decreased MTHFD1 activity (here, insertional mutant heterozygotes) has greater impact on one-carbon metabolism compared with folate-deficient diet; no interaction was observed between MTHFD1 genotype and folate deficiency.

  5. Data suggest that heterozygosity in a lethal Mthfd1 mutation impairs folate status in pregnant mice (i.e., impairs fetal growth) but does not significantly affect homocysteine metabolism (i.e., does not cause neural tube defects).

  6. Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.

  7. MTHFD1 has a role in production of monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria

  8. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

MTHFD1 Protein Profile

Protein Summary

This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.

Gene names and symbols associated with MTHFD1

  • c-1-tetrahydrofolate synthase, cytoplasmic (pug)
  • C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053509509.20)
  • C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053511741.50)
  • C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053511517.60)
  • C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053508207.240)
  • C-1-tetrahydrofolate synthase, cytoplasmic (Tb927.7.1600)
  • C-1-tetrahydrofolate synthase, cytoplasmic (LinJ26.0310)
  • c-1-tetrahydrofolate synthase, cytoplasmic (LinJ30.2930)
  • C-1-tetrahydrofolate synthase, cytoplasmic (LbrM26_V2.0350)
  • c-1-tetrahydrofolate synthase, cytoplasmic (LbrM30_V2.2550)
  • C-1-tetrahydrofolate synthase, cytoplasmic (LmjF26.0320)
  • c-1-tetrahydrofolate synthase, cytoplasmic (LmjF30.2600)
  • c-1-tetrahydrofolate synthase, cytoplasmic (Tsp_00651)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (MTHFD1)
  • C-1-tetrahydrofolate synthase, cytoplasmic (c1tc)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (mthfd1)
  • similar to C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (MTHFD1)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (Mthfd1)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b (mthfd1b)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (Mthfd1)
  • cb325 protein
  • Dcs protein
  • E430024A07Rik protein
  • fc29f07 protein
  • GB13160 protein
  • MTHFC protein
  • Mthfd protein
  • mthfd1 protein
  • Tb07.27M11.970 protein
  • wu:fc29f07 protein
  • zgc:55597 protein

Protein level used designations for MTHFD1

pugilist , C-1-tetrahydrofolate synthase, cytoplasmic , c-1-tetrahydrofolate synthase, cytoplasmic , C1-THF synthase , methylenetetrahydrofolate dehydrogenase 1 , mthfd1 protein , methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase , c-1-tetrahydrofolate synthase, cytoplasmic-like , 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase , cytoplasmic C-1-tetrahydrofolate synthase , C1-tetrahydrofolate synthase , methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase , formyltetrahydrofolate synthetase , methenyltetrahydrofolate cyclohydrolase , methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

GENE ID SPECIES
550749 Apis mellifera
3536457 Trypanosoma cruzi strain CL Brener
3536565 Trypanosoma cruzi strain CL Brener
3547458 Trypanosoma cruzi strain CL Brener
3550685 Trypanosoma cruzi strain CL Brener
3658374 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5069747 Leishmania infantum JPCM5
5071150 Leishmania infantum JPCM5
5416387 Leishmania braziliensis MHOM/BR/75/M2904
5417780 Leishmania braziliensis MHOM/BR/75/M2904
5652762 Leishmania major strain Friedlin
5653804 Leishmania major strain Friedlin
10903890 Trichinella spiralis
100173036 Pongo abelii
100306829 Salmo salar
452965 Pan troglodytes
493369 Xenopus (Silurana) tropicalis
589933 Strongylocentrotus purpuratus
705985 Macaca mulatta
707059 Macaca mulatta
100027684 Monodelphis domestica
100062154 Equus caballus
100467466 Ailuropoda melanoleuca
100634307 Amphimedon queenslandica
4522 Homo sapiens
64300 Rattus norvegicus
380266 Xenopus laevis
423508 Gallus gallus
480352 Canis lupus familiaris
534382 Bos taurus
414382 Sus scrofa
260441 Danio rerio
108156 Mus musculus
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