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Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like Proteins (MTHFD1L)

The protein encoded by MTHFD1L is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. Additionally we are shipping MTHFD1L Antibodies (21) and MTHFD1L Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTHFD1L 25902 Q6UB35
Rat MTHFD1L MTHFD1L 361472  
MTHFD1L 270685 Q3V3R1
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Top MTHFD1L Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

MTHFD1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) Interaction Partners

Human Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) interaction partners

  1. rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.

  2. MTHFD1L rs6922269 genotype is associated with active vitamin B12 (show NDUFB3 Proteins) levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease.

  3. Results indicate that miR-9 and MiR-197 specifically downregulate MTHFD1L in HEK293 and MCF-7 cells and that SNPrs7646 affects miR-197 binding to the MTHFD1L 3' UTR causing gene repression in the presence of the allele associated with neural tube defects.

  4. The rs3832406 polymorphism was associated with isolated cleft lip with or without cleft palate.(MTHFD1L)

  5. This study support a role of MTHFD1L gene in late-onset Alzheimer's disease in a Northern Han Chinese population.

  6. No evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease is found in a sample from a Spanish population.

  7. Prevalence of minor allele A (adenosine) in rs11754661 single nucleotide polymorphism of MTHFD1L contributes to the risk of Alzheimer's disease in a Han population of mainland China.

  8. mitochondrial C1-tetrahydrofolate synthase (show MTHFD1 Proteins) gene structure and tissue distribution

  9. Two of the three alleles of rs3832406 are functionally different and influence the splicing efficiency of the alternate MTHFD1L mRNA transcripts.

  10. Overexpression of C1-tetrahydrofolate synthase (show MTHFD1 Proteins) in fetal Down syndrome brain at the early second trimester may indicate abnormal folate metabolism and may reflect folate deficiency.

Mouse (Murine) Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) interaction partners

  1. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.

  2. Data show that the MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine.

MTHFD1L Protein Profile

Protein Summary

The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MTHFD1L

  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l)
  • 2410004L15Rik protein
  • AI647056 protein
  • dJ292B18.2 protein
  • Fthfsdc1 protein
  • MTC1THFS protein

Protein level used designations for MTHFD1L

10-formyl-THF synthetase , formyltetrahydrofolate synthetase domain containing 1 , monofunctional C1-tetrahydrofolate synthase, mitochondrial , formyltetrahydrofolate synthetase

25902 Homo sapiens
361472 Rattus norvegicus
476245 Canis lupus familiaris
534296 Bos taurus
270685 Mus musculus
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