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The protein encoded by MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Additionally we are shipping MTHFR Antibodies (101) and MTHFR Kits (18) and many more products for this protein.
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Study demonstrated that maternal MTHFR deficiency (i.e., in utero MTHFR deficiency) and early life exposure to vigabatrin separately and together alter the levels of proteins in the glutamatergic synapse
Mildly hyperhomocysteinemic Mthfr+/- mice demonstrate reduced ganglion cell function, thinner NFL (show NEFL Proteins), and mild vasculopathy by 24 weeks.
DNA methylation (show HELLS Proteins) patterns in undifferentiated spermatogonia are relatively stable in culture over time under conditions of altered methionine and MTHFR levels.
Data from Mthfr knockout mice (in homozygous/heterozygous matings) suggest that maternal genotype contributes to sensitivity to arsenic as embryotoxin (i.e., genetic predisposition to fetal resorption/congenital malformation in arsenic poisoning).
our results support an interaction between mild neonatal stress, the MTHFR genotype and sex
investigation of Mthfr regulation in an in vivo mouse model revealed temporal- and tissue-specific regulation that supports important roles for MTHFR in the developing embryo, and in postnatal brain and male reproductive tissues
A possible mechanism for the epigenetic involvement of Mthfr deficiency is proposed in the gender-dependent regulation of proteins associated with plasticity of the excitatory synapse.
These results showed that methylenetetrahydrofolate reductase deficiency impairs endothelial progenitor cell formation and increases endothelial progenitor cell senescence by endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling and downregulation of SIRT1 (show SIRT1 Proteins).
Variable presentation of MTHFR deficiency in different genetic backgrounds; plasma homocysteine is not a predictor of severity.
Newborn reflex development was slightly influenced by Mthfr +/- genotype and by the combination genotype and the neonatal vigabatrin (GVG) administration, in a sex-independent manner. Females presented attenuated anxiety due to Mthfr +/- genotype and GVG.
A significant association between MTHFR gene polymorphisms and p16 and MGMT (show MGMT Proteins) gene promoter methylation was found in oral squamous cell cancer patients.
This review showed that Lack of association between MTHFR A1298C variant and Alzheimer's disease.
Polymorphisms of the FTO (show FTO Proteins) and MTHFR gene are associated with obesity.
this meta-analysis suggested that there is no significant association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility for overall population. [meta-analysis]
The 677TT genotype of the C677T polymorphism in the MTHFR gene is associated with breast cancer (BC) susceptibility in the Mexican population.
analysis of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms association with genetic susceptibility to rheumatoid arthritis [meta-analysis]
genotype of MTHFR 677TT in molar tissue is associated with ineffective MTX (show MTX1 Proteins) treatment in Japanese low-risk GTN (show GNAT3 Proteins) patients
genetic association studies in a population in Iran: Data suggest that an SNP in MTHFR (C677T, rs1801133; but not A1298C, rs1801131) is associated with male infertility in the population studied; men who are carriers of the 677T allele (CT and TT genotypes) exhibit higher propensity to oligospermia than men with other genotypes.
MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and reduced response to short-term folate supplementation [meta-analysis]
Our results indicate that there exist interactive effects of the MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on some lipid traits in Chinese Han population, and the effects were gender-specific.
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
, 5,10-methylenetetrahydrofolate reductase (NADPH)
, methylenetetrahydrofolate reductase (NAD(P)H)
, methylenetetrahydrofolate reductase-like
, methylenetetrahydrofolate reductase