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Methylthioadenosine phosphorylase Proteins (MTAP)

MTAP encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. Additionally we are shipping MTAP Antibodies (52) and MTAP Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTAP 4507 Q13126
MTAP 66902 Q9CQ65
Rat MTAP MTAP 298227  
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Top MTAP Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,735.33
Details
Yeast REACT_Sea Squirt His tag   1 mg Log in to see 56 to 66 Days
$2,735.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,737.17
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,744.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,744.50
Details
Yeast Nematostella vectensis His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
Details
Yeast Ajellomyces capsulata His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details

MTAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced MTAP Proteins

  1. Human MTAP Protein expressed in Wheat germ - ABIN1311524 : Yang, Gee, Gee, Zurita-Lopez, Khare, Clarke, Mamula: Lupus autoimmunity altered by cellular methylation metabolism. in Autoimmunity 2013 (PubMed)

More Proteins for Methylthioadenosine phosphorylase (MTAP) Interaction Partners

Human Methylthioadenosine phosphorylase (MTAP) interaction partners

  1. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.

  2. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors

  3. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma

  4. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1 (show CCND1 Proteins).

  5. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.

  6. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.

  7. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.

  8. Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia.

  9. Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP).

  10. MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity.

Mouse (Murine) Methylthioadenosine phosphorylase (MTAP) interaction partners

  1. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.

  2. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver

  3. Studies show that Mtap is a tumor suppressor gene independent of CDKN2A and ARF.

MTAP Protein Profile

Protein Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Gene names and symbols associated with MTAP

  • methylthioadenosine phosphorylase (mtaP)
  • methylthioadenosine phosphorylase (Mmah_0779)
  • methylthioadenosine phosphorylase (Mmah_0844)
  • methylthioadenosine phosphorylase (Tagg_1015)
  • methylthioadenosine phosphorylase (Slip_0897)
  • methylthioadenosine phosphorylase (Slip_1284)
  • methylthioadenosine phosphorylase (Toce_0364)
  • methylthioadenosine phosphorylase (Vdis_0648)
  • methylthioadenosine phosphorylase (Mfer_0491)
  • methylthioadenosine phosphorylase (Intca_0886)
  • methylthioadenosine phosphorylase (Desmu_1057)
  • methylthioadenosine phosphorylase (Dester_1490)
  • methylthioadenosine phosphorylase (Arcve_1093)
  • methylthioadenosine phosphorylase (Mahau_1873)
  • methylthioadenosine phosphorylase (Mzhil_0273)
  • methylthioadenosine phosphorylase (MTAP)
  • methylthioadenosine phosphorylase (Mtap)
  • methylthioadenosine phosphorylase (mtap)
  • 1300019I21Rik protein
  • BDMF protein
  • c86fus protein
  • Cc1-6 protein
  • DMSFH protein
  • DMSMFH protein
  • LGMBF protein
  • MSAP protein
  • MTAPase protein
  • zgc:66012 protein

Protein level used designations for MTAP

methylthioadenosine phosphorylase , 5'-methylthioadenosine phosphorylase , MTA phosphorylase , MTAPase , MeSAdo phosphorylase , S-methyl-5'-thioadenosine phosphorylase , CG4802-like

GENE ID SPECIES
3230190 Dehalococcoides ethenogenes 195
8982941 Methanohalophilus mahii DSM 5219
8983006 Methanohalophilus mahii DSM 5219
9166038 Thermosphaera aggregans DSM 11486
9273683 Syntrophothermus lipocalidus DSM 12680
9274073 Syntrophothermus lipocalidus DSM 12680
9509999 Thermosediminibacter oceani DSM 16646
9751569 Vulcanisaeta distributa DSM 14429
9962213 Methanothermus fervidus DSM 2088
10083682 Intrasporangium calvum DSM 43043
10153764 Desulfurococcus mucosus DSM 2162
10270747 Desulfurobacterium thermolithotrophum DSM 11699
10394208 Archaeoglobus veneficus SNP6
10608635 Mahella australiensis 50-1 BON
10821877 Methanosalsum zhilinae DSM 4017
4507 Homo sapiens
66902 Mus musculus
298227 Rattus norvegicus
709020 Macaca mulatta
782907 Bos taurus
393526 Danio rerio
Selected quality suppliers for MTAP Proteins (MTAP)
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