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MTAP encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. Additionally we are shipping MTAP Antibodies (52) and MTAP Kits (9) and many more products for this protein.
Showing 10 out of 15 products:
Human MTAP Protein expressed in Wheat germ - ABIN1311524
Yang, Gee, Gee, Zurita-Lopez, Khare, Clarke, Mamula: Lupus autoimmunity altered by cellular methylation metabolism. in Autoimmunity 2013
MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.
study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors
MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma
In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1 (show CCND1 Proteins).
MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.
MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.
SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.
Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia.
Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP).
MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity.
Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver
Studies show that Mtap is a tumor suppressor gene independent of CDKN2A and ARF.
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
, 5'-methylthioadenosine phosphorylase
, MTA phosphorylase
, MeSAdo phosphorylase
, S-methyl-5'-thioadenosine phosphorylase