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MVK encodes the peroxisomal enzyme mevalonate kinase. Additionally we are shipping Mevalonate Kinase Antibodies (85) and Mevalonate Kinase Kits (1) and many more products for this protein.
Showing 10 out of 16 products:
Human MVK Protein expressed in Escherichia coli (E. coli) - ABIN1098525
Cuisset, Drenth, Simon, Vincent, van der Velde Visser, van der Meer, Grateau, Delpech: Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. in European journal of human genetics : EJHG 2001
Show all 2 references for ABIN1098525
Human MVK Protein expressed in Baculovirus infected Insect Cells - ABIN2005998
Schafer, Bishop, Kratunis, Kalinowski, Mosley, Gibson, Tanaka: Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. in The Journal of biological chemistry 1992
this study extends the mutation spectrum of MVK; MVK protein stability and correct folding might be the molecular mechanism causing disseminated superficial actinic porokeratosis
predictive analysis of mutations in MVK to predict disease severity
study reports a novel mutation of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis (DSAP); result confirms the involvement of MVK gene in DSAP
results from this 4 generation family imply a causal relationship between MVK and perokeratosis.
Results suggest that the effects of MVK mutations in Behcet's disease could be an additional genetic susceptibility factor for the patients with neurological involvement.
The testing for the Hyper IgD Syndrome was positive for the pV377I/c.1129 G>A heterozygosity in a patient with periodic fever.
Report a novel missense mutation in mevalonate kinase responsible for disseminated superficial actinic porokeratosis.
study reportstwo novel mutations of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis
These results suggest that hCG (show CGA Proteins)-induced down-regulation of LHR (show LHCGR Proteins) mRNA expression is mediated by activation of cAMP/PKA/ERK (show EPHB2 Proteins) pathways to increase miR (show MLXIP Proteins)-122 expression, which then increases LRBP expression through the activation of SREBPs.
In the current article, we add another phenotype to the spectrum of diverging disorders associated with mutations in MVK.
analyis of the aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome
PTH (show PTH Proteins) stimulated BMP-2 (show BMP2 Proteins) mRNA expression via the mevalonate pathway and ROK (show GRK1 Proteins) in osteoblastic MC3T3-E1 cells
a mevalonate kinase (Mvk) allele deletion yields a murine model of hyper-IgD syndrome
expression of LHR (show LHCGR Proteins) mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater expression of LHR (show LHCGR Proteins) in the bovine dominant follicle
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene.
, LH receptor mRNA-binding protein
, mevalonate kinase 1
, mevalonate kinase (mevalonic aciduria)