You are viewing an incomplete version of our website. Please click to reload the website as full version.

Microphthalmia-Associated Transcription Factor Proteins (MITF)

MITF encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Additionally we are shipping MITF Antibodies (167) and MITF Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MITF 4286 O75030
MITF 17342 Q08874
MITF 25094  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top MITF Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details
HOST_Escherichia coli (E. coli) Human GST tag   10 μg Log in to see 3 to 4 Days
$662.36
Details

MITF Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Microphthalmia-Associated Transcription Factor (MITF) Interaction Partners

Horse (Equine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Accumulating mutations in series of haplotypes at the KIT and MITF loci are major determinants of white markings in Franches-Montagnes horses.

  2. several independent mutations in MITF and PAX3 (show PAX3 Proteins) together with known variants in the EDNRB (show EDNRB Proteins) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.

Human Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Results show that Mitf, probably including Mitf-M, is expressed in the mitral cells and tufted cells that transmit the information derived from olfactory sensory neurons to the olfactory cortex.

  2. SOX5 (show SOX5 Proteins) has a strong inhibitory effect on MITF expression and seems to have a decisive clinical impact on melanoma during tumor progression.

  3. In addition to melanoma risk, MITF p.E318K is associated with a high nevi count and could play a role in fast-growing melanomas.

  4. expression of the molecular marker Mitf in primary cutaneous melanomas is a useful tool in assessing lymph node status.

  5. an MITF-CEACAM1 (show CEACAM1 Proteins) axis is suggested as a potential determinant of melanoma progression.

  6. LEF-1 (show LEF1 Proteins) and MITF regulate tyrosinase (show TYR Proteins) gene transcription in vitro via binding to its promoter.

  7. Here we show that MITF-A mRNA is predominantly expressed in all three human liver cancer cell lines examined.

  8. Data show that mutant microphthalmia-associated transcription factor (MITF) with loss of localization signals (NLS (show ALDH1A2 Proteins)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR (show TYR Proteins)), which can cause Waardenburg syndrome.

  9. Data suggest that the heterozygous deletion mutation c.649_651delAGA in exon 7 of the microphthalmia-associated transcription factor (MITF) gene probably underlies the disease in the first family.

  10. A reciprocal antagonism between the MITF and c-Jun (show JUN Proteins) interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment.

Mouse (Murine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Results show that Mitf, probably including Mitf-M, is expressed in the mitral cells and tufted cells that transmit the information derived from olfactory sensory neurons to the olfactory cortex.

  2. Therefore, it is reasonable to assume that the increase in the expression of Mitf in melanocytes is involved in the age-ssociated increase in the pigmentation in the eyes of black-eyed mice.

  3. MITF interacts with BRG1 (show SMARCA4 Proteins) to promote GATA4 (show GATA4 Proteins) expression in cardiac hypertrophy.

  4. Overexpression of FHL2 (show FHL2 Proteins) alone had no effect on Erbin (show ERBB2IP Proteins) expression, but in the presence of MITF, Erbin (show ERBB2IP Proteins) expression was decreased.

  5. A reciprocal antagonism between the MITF and c-Jun (show JUN Proteins) interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment.

  6. BPTF likely acts as a cofactor for other transcription factors in MITF-negative melanoma cells and there are clearly genes regulated by BPTF, but not MITF, in MITF-expressing lines.

  7. the crucial role of signaling dependent MITF/p38 MAPK (show MAPK14 Proteins) interactions in osteoclast differentiation

  8. HDAC7 (show HDAC7 Proteins) in osteoclasts is an important molecular regulator of MITF activity and bone homeostasis.

  9. MITF-BRG1 (show SMARCA4 Proteins) interplay thus plays an essential role in transcription regulation in melanoma.

  10. Expression of microRNA-211 is regulated by the key melanocyte transcription factor MITF and regulates pigmentation by targeting the TGF-beta (show TGFB1 Proteins) receptor 2.

Cow (Bovine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Variability in the MITF gene clearly explained the differences between spotted and non-spotted cattle phenotypes but, at the same time, it is evident that this gene is not the only genetic factor determining piebaldism in two of the studied cattle breeds.

  2. The objectives of this study were to characterize the phenotypes of German White Fleckvieh and to identify the mutation responsible for this newly detected phenotype in cattle using genome-wide association analyses and re-sequencing of MITF.

Pig (Porcine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Although MITF does not seem to be the causal gene of the QTL initially observed, it can not be excluded that a prominent role of its transcription and function in the outbreak and evolution of the tumors observed in pigs.

MITF Protein Profile

Protein Summary

This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with MITF

  • microphthalmia-associated transcription factor (MITF)
  • microphthalmia-associated transcription factor (mitf)
  • microphthalmia-associated transcription factor (LOC100313655)
  • microphthalmia-associated transcription factor (mitf-b)
  • microphthalmia-associated transcription factor (mitf-A)
  • Microphthalmia (MICROP)
  • microphthalmia-associated transcription factor (Mitf)
  • BCC2 protein
  • Bhlhe32 protein
  • bw protein
  • CMI9 protein
  • CMM8 protein
  • Gsfbcc2 protein
  • LOC100313655 protein
  • mi protein
  • MITF protein
  • MITF-A protein
  • MITF-H protein
  • MITF-M protein
  • mitfa protein
  • mitfb protein
  • vit protein
  • Vitiligo protein
  • Wh protein
  • WS2 protein
  • WS2A protein

Protein level used designations for MITF

microphthalmia transcription factor , microphthalmia-associated transcription factor , micophthalmia-associated transcription factor b , class E basic helix-loop-helix protein 32 , black eyed white , transcription factor , microphtalmia-associated transcription factor

GENE ID SPECIES
100033918 Equus caballus
460500 Pan troglodytes
100101790 Xenopus (Silurana) tropicalis
100313655 Saccoglossus kowalevskii
100337579 Xenopus laevis
100534525 Oreochromis niloticus
100599577 Nomascus leucogenys
100532953 Ovis aries
4286 Homo sapiens
17342 Mus musculus
25094 Rattus norvegicus
407219 Bos taurus
415126 Canis lupus familiaris
395886 Gallus gallus
414902 Sus scrofa
Selected quality suppliers for MITF Proteins (MITF)
Did you look for something else?