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The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Additionally we are shipping MGST1 Antibodies (36) and MGST1 Kits (15) and many more products for this protein.
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possibly marked variations in NB mitochondrial homeostasis, they also imply that the results of these earlier studies using NB cells are not transferable to other tumor and cell types that express MGST1 at high concentrations.
Differential expression of SOD2 (show SOD2 Proteins), ALDH1A1 (show ALDH1A1 Proteins), and MGST1 genes in the anterior lens capsules of patients with pseudoexfoliation syndrome suggest that diseased tissue appears to respond to the previously reported oxidative stress.
The results suggest that MGST1 gene polymorphisms as one of environment gene may contribute to colorectal cancer risk in younger ages.
MGST1 protects cells (and mitochondria) by both conjugation and glutathione peroxidase (show GPX1 Proteins) functions. A new protective mechanism against cisplatin is also indicated
Polymorphisms in microsomal glutathione s transferase (show GSTa2 Proteins) is associated with laryngeal cancer
The results indicate that Sp1 (show PSG1 Proteins) is the protein mediating the basal transcription of MGST1
Genes encoding KU70 (show XRCC6 Proteins), MGST1 and BIK (show BIK Proteins) show age-related mRNA expression levels in hematopoietic stem cells.
As an addition to the high-density SNP (single-nucleotide polymorphism) maps of 12 glutathione S-transferase (show GSTa2 Proteins) and related genes reported earlier, a SNP map of the microsomal glutathione S-transferase 1 (MGST1) gene is provided.
identification of the promoter region and a comprehensive examination of tissue expression of MGST1
MGST1 is a dominant, highly expressed enzyme in mouse retinal pigme (show RPE Proteins)nt epithelium (RPE) microsomes that displays an important protective function against oxidativ (show RPE Proteins)e insult in the RPE that decreases with age.
Gst genes are extensively downregulated in primary but not metastatic TRAMP (show DPT Proteins) tumors.
MGST1 is highly expressed in bovine retinal pigment epithelium (RPE (show RPE Proteins)) microsomes and displays an important protective function against oxidative insult in the RPE (show RPE Proteins).
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.
microsomal glutathione S-transferase 1
, glutathione S-transferase 12
, microsomal GST-1
, microsomal GST-I
, glutathione S-transferase