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Microsomal Triglyceride Transfer Protein Proteins (MTTP)

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Additionally we are shipping MTTP Antibodies (45) and MTTP Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTTP 17777 O08601
Rat MTTP MTTP 310900  
MTTP 4547 P55157
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Top MTTP Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MTTP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Microsomal Triglyceride Transfer Protein (MTTP) Interaction Partners

Fruit Fly (Drosophila melanogaster) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. promotes assembly and secretion of human apolipoprotein B (show APOB Proteins)

  2. the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (show APOB Proteins) lipoproteins

Zebrafish Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit

  2. In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.

Pig (Porcine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.

  2. There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.

Cow (Bovine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE (show APOE Proteins), MTP, and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

  2. after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (show APOE Proteins) messenger RNA abundance were higher in the liver

  3. measurements of the transfer of phospholipids (PLs (show CTSC Proteins)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity

Mouse (Murine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. The results suggest that physiologic hepcidin (show HAMP Proteins) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.

  2. PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (show TSPO Proteins) LIGANDS

  3. In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Proteins) and ferroportin (show SLC40A1 Proteins) expression levels were increased and hepatic hepcidin (show HAMP Proteins) mRNA expression and serum hepcidin (show HAMP Proteins) concentration were reduced.

  4. Intestine-specific MTP (show LAPTM4A Proteins) and global ACAT2 (show SOAT2 Proteins) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Proteins)

  5. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1 (show SLC40A1 Proteins), consistent with increased uptake of dietary iron.

  6. Results suggest that reduction in ferroportin (show SLC40A1 Proteins) levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself

  7. intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice

  8. identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta (show CEBPB Proteins) and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes

  9. effects of reducing either systemic or liver-specific MTP (show LAPTM4A Proteins) activity on cholesterol metabolism and reverse cholesterol transport

  10. Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp (show FABP1 Proteins)) are protected from lithogenic diet (LD)-induced gallstone formation.

Human Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

  1. the N-terminal domain of MTP (show MT1B Proteins) is important for its lipid transfer activity

  2. These studies indicated that SAP18 (show SAP18 Proteins) expression enhanced the recruitment of mSin3A in coordination with TRIB1 (show TRIB1 Proteins) to MTTP regulatory elements and increased MTTP expression.

  3. Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease.

  4. Findings from meta-analysis indicate that the MTP (show MT1B Proteins) -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP (show MT1B Proteins) -493G/T polymorphism may be a biomarker for the early detection of the disease.

  5. Homozygous MTTP mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia.

  6. MTTP SNPs (GG, GT, TT) and alleles (G, T) in the chronic hepatitis C (genotype 4) patients versus the uninfected controls were 70%, 21%, 9% & 80.5%, 19.5% versus 10%, 87.5%, 2.5% & 53.8%, 46.3%, respectively (p=0.0001).

  7. The MTP (show MT1B Proteins)-493G/T polymorphism modulates postprandial apoB48 and apoB100 (show APOB Proteins) of triglyceride-rich lipoproteins in familial combined hyperlipidemia

  8. Case Reports: novel mutation in MTTP gene responsible for abetalipoproteinemia in Tunisian families.

  9. Report of two new mutations of MTTP, a nonsense mutation c.2313T > A leading to a truncated protein (p.Y771X) and a splice mutation IVS 9 + 2T > G, in abetalipoproteinemia

  10. MTTP genetic polymorphisms influence the susceptibility to developing NAFLD in the Han Chinese population.

MTTP Protein Profile

Protein Summary

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Gene names and symbols associated with MTTP

  • Microsomal triacylglycerol transfer protein (Mtp)
  • microsomal triglyceride transfer protein (mtp)
  • microsomal triglyceride transfer protein (MTTP)
  • microsomal triglyceride transfer protein (Mttp)
  • mitochondrially encoded tRNA proline (MT-TP)
  • solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)
  • 1810043K16Rik protein
  • ABL protein
  • CG9342 protein
  • CT3751 protein
  • Dmel\\CG9342 protein
  • dMTP protein
  • Dusg protein
  • Fpn1 protein
  • IREG1 protein
  • MTP protein
  • MTP1 protein
  • MTTP protein
  • Ol5 protein
  • Pcm protein
  • Slc11a3 protein
  • Slc39a1 protein
  • wu:fd36b01 protein
  • zgc:111876 protein

Protein level used designations for MTTP

microsomal triacylglycerol transfer protein , CG9342-PA , Mtp-PA , microsomal triglyceride transfer protein , microsomal triglyceride transfer protein large subunit , stalactite , stl , microsomal triglyceride transfer protein (large polypeptide, 88kDa) , microsomal triglyceride transfer protein B , microsomal triglyceride transfer protein, large subunit , SLC11A3 iron transporter , duodenal-specific , ferroportin 1 , ferroportin-1 , iron-regulated transporter 1 , metal transporter protein 1 , metal transporting protein 1 , polycythaemia , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 , solute carrier family 39 (iron-regulated transporter), member 1 , solute carrier family 40 member 1

GENE ID SPECIES
35362 Drosophila melanogaster
406207 Danio rerio
471397 Pan troglodytes
422709 Gallus gallus
487873 Canis lupus familiaris
397381 Sus scrofa
280868 Bos taurus
17777 Mus musculus
310900 Rattus norvegicus
4547 Homo sapiens
100734244 Cavia porcellus
100341961 Oryctolagus cuniculus
101110939 Ovis aries
101836921 Mesocricetus auratus
4571 Homo sapiens
53945 Mus musculus
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