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Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. Additionally we are shipping MCRS1 Kits (8) and MCRS1 Proteins (3) and many more products for this protein.
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Human Polyclonal MCRS1 Primary Antibody for IF, IHC (p) - ABIN523843
Xu, Zheng, Zhang, Zhao, Zhang, Wu, Wu, Wang, Wang, Zhang: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo. in Asian Pacific journal of cancer prevention : APJCP 2012
Show all 2 Pubmed References
Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin (show PCNA Antibodies) gene promoters.
MCRS1 is phosphorylated by the Aurora-A kinase (show AURKA Antibodies) in mitosis on Ser35/36.
RINT-1 (show RINT1 Antibodies) interacts with MSP58 and UBF (show UBTF Antibodies) within nucleoli and plays a role in ribosomal gene transcription.
The immunoreactivity score (IRS (show IARS Antibodies)) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 (show MKI67 Antibodies) index (r = 0.65, P < 0.001).
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients.
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR (show MLXIP Antibodies)-155-Rb1 (show RB1 Antibodies) pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer.
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58.
BAP1 (show RNF2 Antibodies) loss and MCRS1 down-regulation in renal cell carcinoma (show MOK Antibodies) are associated with adverse clinicopathological features.
MiR (show MLXIP Antibodies)-129* down-regulation induced MCRS1 overexpression.
High expression of MSP58 was also an independent unfavorable prognostic factor.
MSP58 could suppress the transcription of hTERT promoter.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
, lethal (3) rG166
, reduction in Cnn dots 5
, microspherule protein 1
, microspherule protein 1-like
, 58 kDa microspherule protein
, nucleolar protein
, INO80 complex subunit J
, INO80 complex subunit Q
, cell cycle-regulated factor (78 kDa)
, cell cycle-regulated factor p78