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Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. Additionally we are shipping MCRS1 Antibodies (34) and MCRS1 Proteins (3) and many more products for this protein.
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Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin (show PCNA ELISA Kits) gene promoters.
MCRS1 is phosphorylated by the Aurora-A kinase (show AURKA ELISA Kits) in mitosis on Ser35/36.
RINT-1 interacts with MSP58 and UBF (show UBTF ELISA Kits) within nucleoli and plays a role in ribosomal gene transcription.
The immunoreactivity score (IRS (show IARS ELISA Kits)) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 (show MKI67 ELISA Kits) index (r = 0.65, P < 0.001).
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients.
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR (show MLXIP ELISA Kits)-155-Rb1 (show RB1 ELISA Kits) pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer.
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58.
BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features.
MiR (show MLXIP ELISA Kits)-129* down-regulation induced MCRS1 overexpression.
High expression of MSP58 was also an independent unfavorable prognostic factor.
MSP58 could suppress the transcription of hTERT promoter.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
, lethal (3) rG166
, reduction in Cnn dots 5
, microspherule protein 1
, microspherule protein 1-like
, 58 kDa microspherule protein
, nucleolar protein
, INO80 complex subunit J
, INO80 complex subunit Q
, cell cycle-regulated factor (78 kDa)
, cell cycle-regulated factor p78