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Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Additionally we are shipping MICAL1 Proteins (5) and many more products for this protein.
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Human Polyclonal MICAL1 Primary Antibody for WB - ABIN528693
Dutta, Donaldson: Sorting of Clathrin-Independent Cargo Proteins Depends on Rab35 Delivered by Clathrin-Mediated Endocytosis. in Traffic (Copenhagen, Denmark) 2015
The results provide evidence that MICAL1 plays an essential role in the activation of ROS (show ROS1 Antibodies)/Akt (show AKT1 Antibodies) signaling and cell invasive phenotype and identify a novel link between RAB35 (show RAB35 Antibodies) and MICAL1 in regulating breast cancer cell invasion.
Data suggest that Sema6A (show SEMA6A Antibodies) and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma.
The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS (show ROS1 Antibodies) production by MICAL1 also causes oxidation of collapsin response mediator protein-2 (show DPYSL2 Antibodies) which subsequently undergoes phosphorylation.
although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation
Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects.
Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST (show MAP3K10 Antibodies)-NDR (show STK38 Antibodies) signaling.
a CasL interacting molecule that associates with vimentin (show VIM Antibodies)
MICAL-1 isoforms with their multidomain structure are novel rab1 (show RAB1A Antibodies) interacting proteins that function as scaffold proteins connecting different components in the cell.
The unfolding of MICAL-1 calpolnin homology (CH) domain was studied.
esults suggest that the CH domain, which is loosely connected to the MO domain by a flexible linker and is far away from the catalytic site, couples F-actin to the enhancement of redox activity of MICALMO-CH by a cooperative mechanism involving a trans interaction between adjacently bound molecules.
MICAL-1 regulates the targeting of secretory vesicles containing immunoglobulin superfamily cell adhesion molecules (IgCAMs) to the neuronal growth cone membrane through its ability to control the actin cytoskeleton using redox chemistry.
Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR (show STK38 Antibodies) signaling.
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L\; acts by antagonizing STK38 and STK38L activation by MST1/STK4 (By similarity).
microtubule associated monoxygenase, calponin and LIM domain containing 1
, CasL interacting molecule
, NEDD9 interacting protein with calponin homology and LIM domains
, NEDD9-interacting protein with calponin homology and LIM domains
, molecule interacting with CasL protein 1
, protein-methionine sulfoxide oxidase MICAL1
, CasL interacting molecule MICAL
, molecule interacting with CasL 1
, microtubule associated monooxygenase, calponin and LIM domain containing 1